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Laboratory Tips Safety proceedures, test reagents, drilling rubber stoppers, bending glass tubes, etc. Contributed to by chemists.

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 #1 
Old 2002-02-16, 05:38
bako bako is offline
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Default lsa and naptha

hey has anyone tried an lsa extraction using ronsonol lighter fluid(naptha, heptane), does it disolve some of the lsa along with the toxins and make a weaker product?
 #2 
Old 2002-02-17, 21:09
acidmelt acidmelt is offline
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Default Re: lsa and naptha

sometimes i just dont understand why people use those weak ass extractions for LSA. If your gonna do something, do it right the first time. Just for fun I decided to pull the LSA extraction out of madchemist new LSD synth on our site Chemhead. He uses baby hawaiins for this method, but morning glorys will work.
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Preparation of crude lysergic acid from BHWR seeds:

(Warning, when performing all of these procedures, use dim red light, avoid bright direct light of any kind. Also, when a solvent is evaporated, use either vacuum, or do it under a fume hood, in the dark, with a couple of fans blowing across it. DO NOT HEAT IT for EVAPORATION.)

Chemicals:

toluene
methanol (MeOH)
potassium hydroxide (KOH)
dH2O
N2 source or N2O
HCl

1-Grind up 1kg of seeds to a powder. Place it in two or three volumes of toluene.
2-Let this mixture soak for a week or two, with occasional shaking.
3-Filter out seed mush. Spread it out and allow it to dry completely.
4-Add two or three volumes of methanol to the dry seed powder, and allow that to soak for one to two weeks.
5-Filter out seed mush, and discard it.
6-Allow methanol to evaporate.
7-The residue left is taken up in 200mL of an 8% KOH in water per 10g crude amides.
8-It is setup In a three necked flask. The middle neck is equipped with a plugged condensor. The first neck is fitted with a N2 or N2O feed. The Third neck is fitted with an exaust tube that runs to the bottom of a water/HCl solution adjusted to a pH of 3 or 4.
9-Warm the solution on a steam bath. As the reaction progress's, NH3 is formed. This will get bubbled throught the HCl solution. This is how you follow the reaction. The NH3 reacts with HCl, and brings the pH up. So when the pH stops rising, the rxn is done. If the pH rises above 7, then more HCl can be added to bring the pH back down.
10-When reaction is finished, neutralize solution (pH 7) with HCl, then evaporate the water.
11-Add several volumes of dry methanol to the residue left, and filter out the insoluables.
12-Evaporate the methanol to obatin d,l-LSA, d,l-isoLSA, and impurities. This however, according to the patents mentioned above, can be used in production of LSD through the proposed route.


 
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