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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, making beer, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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 #1 
Old 2001-06-13, 16:08
Bubble Bubble is offline
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Default Morphine Sulphate HELP!!!

Hi,
I take morphine sulphate sustained release pellets (Kapanol) for pain 300mg in the morning and 300mg at night. It doesn't give you the high that an injection of morphine does. Anyone know if & how to get that type of high from the Kapanol. What to do? How much to take as I am on a high dose?
I don't smoke mj as it makes me feel awful and I also don't drink. I know only because of my accident that I do like the feeling I get from a mophine inj. I was reading about morphine on this site and it said that you could smoke it, has anyone tried, and what sort of high was it? I would be smoking it with tobacco I do smoke that. How much would you put with the tobacco and how long would it take to work.

Thanks Bubble.

 #2 
Old 2001-06-14, 02:55
slpwlkr333 slpwlkr333 is offline
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Default Re: Morphine Sulphate HELP!!!

*Thumbs up* Moron!
 #3 
Old 2001-06-14, 06:38
Bubble Bubble is offline
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Default Re: Morphine Sulphate HELP!!!

Who do you think you are? I wrote in to this site for information not to be abused. Show some respect for others that aren't as informed as you think you are.

Bubble.
 #4 
Old 2001-06-14, 08:10
slpwlkr333 slpwlkr333 is offline
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Default Re: Morphine Sulphate HELP!!!

i think i dont live in a bubble

cool handle by the way. it screams streisand.
 #5 
Old 2001-06-14, 15:53
Bubble Bubble is offline
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Default Re: Morphine Sulphate HELP!!!

When I first came on to this site last night I was reading a few posts and thought I hope Sleepwalker 333 answers my question because they sound intelligent and knowledgeable but as the old saying goes you can't judge a book by its cover. If you think you are so smart why don't you just answer my original question.

Bubble
 #6 
Old 2001-06-15, 01:04
slpwlkr333 slpwlkr333 is offline
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Default Re: Morphine Sulphate HELP!!!

uh hum sorry for hurting your feelings there.

well i cant find info on kapanol but i can find basically every other kind of morphine sulphate sr pill out there. which means that the binders you would have to get rid of to inject it IV would be Lactose, Hydroxypropyl Methylcellulose, Colloidal Silicon Dioxide, and Stearic Acid- TOO MUCH SHIT. sr pills are such a fuckin bitch to clean it sucks ass, i cant believe you cant just take a larger oral dose or crush them to get it all at once to get a fuckin FINE-ASS high goin on.

smoking would be nice with cleaned pills but if you are completely lazy and shit, well it is an at your own risk thing. i mean the sr binders will make it taste worse than a normal pill since they are normally completely synthetic and can cause all sorts of health(mostly resperatory) problems in the long run. i mean there isnt a lot of the shit in there at all so it isnt a big worry, but smoking them habitually just wouldnt be smart.

damn 300 mgs is a lot. so that brings me to my next order- wanna get this shit the fuck out? well for starters if ya just wanna do a kitchen chemists extraction. a cold water extraction will do the trick(thoroughly thoroughly crushed!!!). this product will be smokable. next if you are going to want to inject it. inquire again in this post for further instructions on cleaning the binders out.
 #7 
Old 2001-06-15, 02:58
Trippy_McGee Trippy_McGee is offline
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Default Re: Morphine Sulphate HELP!!!

You could try snorting it, if you don't mind that horribly opiate taste.
 #8 
Old 2001-06-15, 06:19
Bubble Bubble is offline
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Default Re: Morphine Sulphate HELP!!!

quote:
Originally posted by slpwlkr333:
uh hum sorry for hurting your feelings there.

well i cant find info on kapanol but i can find basically every other kind of morphine sulphate sr pill out there. which means that the binders you would have to get rid of to inject it IV would be Lactose, Hydroxypropyl Methylcellulose, Colloidal Silicon Dioxide, and Stearic Acid- TOO MUCH SHIT. sr pills are such a fuckin bitch to clean it sucks ass, i cant believe you cant just take a larger oral dose or crush them to get it all at once to get a fuckin FINE-ASS high goin on.

smoking would be nice with cleaned pills but if you are completely lazy and shit, well it is an at your own risk thing. i mean the sr binders will make it taste worse than a normal pill since they are normally completely synthetic and can cause all sorts of health(mostly resperatory) problems in the long run. i mean there isnt a lot of the shit in there at all so it isnt a big worry, but smoking them habitually just wouldnt be smart.

damn 300 mgs is a lot. so that brings me to my next order- wanna get this shit the fuck out? well for starters if ya just wanna do a kitchen chemists extraction. a cold water extraction will do the trick(thoroughly thoroughly crushed!!!). this product will be smokable. next if you are going to want to inject it. inquire again in this post for further instructions on cleaning the binders out.



Thanks very much for that. Why couldn,t you have answered that nicely the first time? I am not into any self injections and as far as the chemistry goes so best leaving all alone.
Thanks again bubble
 #9 
Old 2001-06-15, 06:22
slpwlkr333 slpwlkr333 is offline
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Default Re: Morphine Sulphate HELP!!!

yea, opiates and opioids are some ass nasty bitter tasting shit.
 #10 
Old 2001-06-15, 15:33
sckbch sckbch is offline
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Default Re: Morphine Sulphate HELP!!!

KAPANOL:
KAPANOL - (AUSTRALIA)
KAPANOL - (NETHERLANDS)
KAPANOL - (AUSTRIA)
KAPANOL - (NORWAY)
KAPANOL - (DENMARK)
KAPANOL - (MEXICO)

so, since you're in australia, we'll pull the australian records -

KAPANOL
Related Documents: DEXTROMETHORPHAN/MORPHINE

Form: (Form Not Given)
Active Ingredient: Morphine sulphate, Dextromethorphan
Availability: AUSTRALIA
Manufacturer: Contact information not available.

A. Dextromethorphan (an N-methyl-D-aspartate (NMDA) antagonist) and morphine (an opioid analgesic) have been formulated as an oral 1:1 fixed combination for the treatment of pain.
B. DOSING INFORMATION: Clinical dosing information for the 1:1 fixed-dose combination have not been published. Dextromethorphan 120 milligrams (mg) plus morphine 60 mg (given separately) has been given for dental surgery pain. To reduce the need for postoperative patient-controlled morphine analgesia following abdominal surgery, oral dextromethorphan 40 mg has been given before and after surgery, followed by 40 mg three times daily for 2 days (total of 8 doses).
C. PHARMACOKINETICS: Pharmacokinetic data for the fixed-combination are unavailable. Dextromethorphan is metabolized in the liver to dextrorphan, which is more potent than the parent compound as an NMDA antagonist.
D. CAUTIONS: In unpublished studies, no increase in adverse effects was reported with the fixed-combination compared to morphine alone in chronic pain patients.
E. CLINICAL APPLICATIONS: The manufacturer has indicated that fixed-dose oral dextromethorphan/morphine is at least as effective as morphine alone in chronic pain; however, results of these studies are unavailable and the FDA did not approve the combination for this indication. The combination of these agents has been investigated in acute dental pain. Oral or intravenous dextromethorphan has reduced postoperative morphine requirements in abdominal surgery patients in some studies.

1. This evaluation emphasizes the fixed oral combination of dextromethorphan/morphine for pain syndromes; peripheral data have been added for clinical perspective only. For more detailed information regarding the pharmacology, pharmacokinetics, therapeutic uses, dosage, and adverse effects of dextromethorphan or morphine given singly or in combination, their individual Drug Evaluations should be consulted.

THERAPEUTIC DRUG CONCENTRATION:
1. Based on doses required for efficacy, relatively high and prolonged plasma levels of dextromethorphan may be required to significantly augment morphine analgesia and reduce tolerance (Henderson et al, 1999; Chia et al, 1999; Mercadante et al, 1998). Specific correlations of plasma levels and clinical effect have not been performed.
B. TIME TO PEAK CONCENTRATION:
1. IMPORTANT NOTE: This evaluation emphasizes the fixed oral combination of dextromethorphan/morphine; peripheral data have been added for clinical perspective only. For detailed information regarding the pharmacokinetics of dextromethorphan or morphine, their individual Drug Evaluations should be consulted.
2. Specific pharmacokinetic data following oral doses of the 1:1 fixed combination of dextromethorphan/morphine have not been published.

PRECAUTIONS
A. Renal impairment (potential accumulation of active metabolite of dextromethorphan (dextrorphan) and toxicity; enhanced risk of respiratory depression and sedation from morphine component, possibly attributed to morphine-6-glucuronide accumulation; consideration of dose adjustments based on patient response)
B. Hepatic dysfunction (potential accumulation of dextromethorphan and morphine with prolonged durations; consideration of dose adjustment based on patient response)
C. Diarrhea related to antibiotics or toxins (potential for exacerbation/prolongation due to slowed elimination (morphine))
D. History of allergic reactions to other opioids, or asthma, allergies, or allergic-type reactions to other medications (enhanced risk of hypersensitivity)
E. Emotional instability or history of drug dependence (applies mainly to non-cancer patients; enhanced risk of physical dependence)
F. Head injury/intracranial lesions (risk of further elevation of cerebrospinal fluid pressure related to hypercapnia (morphine); miosis/sedation may obscure clinical course (morphine))
G. Respiratory disorders characterized by chronic hypoxia (risk of severe hypoventilation (morphine))
H. Patients with excessive respiratory secretions (eg, COPD) (suppression of cough and cough reflex)
I. Reduced blood volume or presence of shock (orthostatic hypotensive effects (morphine))
J. Patients with prostatic hypertrophy or urethral stricture (potential for acute urinary retention (morphine))
K. Severe inflammatory bowel disease (potential for toxic megacolon (morphine))
L. Pregnancy (potential for neonatal withdrawal symptoms)
M. Concomitant zidovudine therapy (potential for reduced clearance of zidovudine (morphine))


ADVERSE EFFECTS - GENERAL
1. The Dextromethorphan and Morphine Drug Evaluations should be consulted for more specific adverse effect data.
2. In unpublished studies, the 1:1 fixed combination of dextromethorphan/morphine (doses unspecified) was not associated with an increased incidence of adverse effects compared to oral morphine alone (Anon, 1998; Anon, 1998a).
3. When given before or with postoperative and/or perioperative morphine in patients undergoing abdominal surgery, dextromethorphan has not produced a significant increase in adverse effects compared to morphine alone. Dizziness, nausea, vomiting, heartburn, constipation, and hot flushes possibly related to adjunctive dextromethorphan have been reported slightly more often than with placebo in few studies (Henderson et al, 1999; McConaghy et al, 1998), but these differences were not clinically relevant. Sedation has occurred with similar frequency in dextromethorphan and placebo groups (McConaghy et al, 1998).
4. Adverse effects of high doses of dextromethorphan alone have included dizziness, sedation or excitement/nervousness, nausea, vomiting, confusion, toxic psychosis, and respiratory depression.


i hate doing your work for you. consider this a favor. because i'm still recovering from grad school.


[This message has been edited by sckbch (edited 06-15-2001).]
 #11 
Old 2001-06-16, 04:42
baked baked is offline
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Default Re: Morphine Sulphate HELP!!!

way to go all out sckbch O.A.
 
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