Well my friend is planning to roll for the first time with a tested 125 mg mdma/25 dex-amph pill this friday for her prom. She is on some heavy medication though. She already stopped taking her SSRI-paxil 20 mg/day until her roll has closed off, she stopped that about a week ago and she's rolling on May 18th.

So i wanna know if anyone knows about what she should do about the 100 mgs wellbutrin(bupropion hcl) she's on, which is very chemically similar to diethylpropion, a phenethylamine, like E, as well as the topamax(topiramate) which is a mood stabalizer/anti-pileptic. Not much is known about topiramate, so i was hoping someone had some serious valuable info for my friend. I pulled this from Rx list if it helps:

electrophysiological and biochemical studies of the effects of topiramate on cultured neurons have revealed three properties that may contribute to topiramate's antiepileptic efficacy. First, action potentials elicited repetitively by a sustained depolarization of the neurons are blocked by topiramate in a time-dependent manner, suggestive of a state-dependent sodium channel blocking action. Second, topiramate increases the frequency at which g-aminobutyrate (GABA) activates GABA A receptors, and enhances the ability of GABA to induce a flux of chloride ions into neurons, suggesting that topiramate potentiates the activity of this inhibitory neurotransmitter

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hope that helps, since im not completely familiar with all of that, nor do i have the capacity at the moment to do so.

Ok so basically i just wanna know will the wellbutrin enhance/decrease, the roll, and the same for the topamax, since the last resort option is cutting back or completely stopping the medications(though completely stopping is a DEFINATE last resort). If there will be any toxic reactions she can definately ween herself off the meds for the time being since it will be temporary(i know this isnt recomended, but you only live once). Ok, well any help would be appriciated ASAP, thanks, friday is coming in fast .

Ok stopping the paxil was a good thing the others Im not sure what to do about right now but Ill look into it a bit. Also perhaps your friend wish's to preload on some 5htp, can be bought legally in most herbal supplement shops, a few hours before the roll this will increase steratonin production in the brain. Steratonin being the main thing released by MDMA or E. And a few hours after the roll taking some Paxil seems to have been found in Lab Rats to stop any potential Nuero Transmitter destruction.

I don't really know what to tell ya except I've experienced rolls plenty of times while taking wellbutrin...but I wouldn't recommend that everyone do as I've done. Comparatively speaking, I'd say that the effects of my roll were increased by wellbutrin. Topiramate...I don't know. I've taken klonepams, recreationally, while rolling and that's somewhat similar but I really don't have any strong advice. Sorry.

she refuses to pre-load on anything her first time that isn't prescribed, i mean add anything in that is, especially since the pill has been compeletly identified as incredably strong- like i said - 125 mg mdma/ 25 mg dextro amphetamine, plus she has dextro amphetamine for post loading and preloading if she wants, but as far as increased seratonin production with tryptophan and stuff, since she has a slight seratonin problem she doesn't wanna overload and produce way too much for release since post-roll depression is a worry here, and she is going to post-load on paxil and start up her paxil again.

lemme get this straight, ur friends on like 18 different kinds of meds for Mental Health reasons an now shes going to dirupt that shit and take some street drugs? Right on!

some people just shouldnt take drugs, when they do shit happens an the whole of drug users get an even worse rep...

Idiot! That's why he's asking for information on top of the info. he found. I bet you haven't researched half the shit you've done before you used it anyway.

Paxil has been out of the picture for over a week now- she has been fine without it.

2 medications, just 2, one being a modest dose, the other a very low dose:

Wellbutrin(bupropion)-100 mg/day (low/very low)(morning)
Topamax(topiramate)-125 mg/day (modest)(50 mg morning, 75 mg nightly[occasionally skips this to lower serum levels slightly, like every 3 days skips nightly])

The pill- is not a street drug. It was never on the street, was not cheaply manufactured, and was actually made by someone she knows:

125 mg mdma/ 25 mg d-amphetamine pressed in front of her. She has pharmaceutical grade dextro-amphetamine to pre-load on too. or load while rolling if necassary to make up for not taking 5htp since she refuses that option.

Are we clear? She is going to roll REGARLESS. She just wants to know if she should stop taking the wellbutrin and/or the topamax if ABSOLUTELY necassary, and if it is safe to roll on these two medications, what the possible interaction she can expect. So can we please avoid being judgemental, since we all know what we are doing here, and are just looking for some serious, hardcore, probably clinical information.