As i stumbled into the bathroom lastnight high off my ass and fuckin pissed as hell cause i couldnt get onto totse in the latenight after my smoke i noticed the name of my moms migraine medication on the counter- IMITREX(sumatriptan)50 mg Manufactured by Cerenex Pharmeceuticals. Ok big deal, so your mom has bad headaches, good cause your an asshole. Is that what you're thinking. Ok, that's reasonable, but check this out. I decided to look up IMITREX(sumatriptan) on RXlist just to see if it had any value like the old cyclobenzaprine i found of my dads, and the old benztropine of mine i'd previously discovered where a lotta fuckin fun.

IMITREX(sumatriptan) is 5-Hydroxytyptamine sorta similar to 5-HTP(5-hydroxytryptophan) like as in relation to serotonin production and all that nice shit. Pharmaceutical marketing wise its sorta like dronabinol(marinol) being 9-tetrahydrocannabinol, the main active chemical compound in weed marketed under a whole web of fucked up names.

So since IMITREX(sumatriptan) is a tryptamine i tried to find out if Shulgin had experimented with it at all but no luck . So i'm asking for your help. anyone got any info on 5-hydroxytryptamine, Imitrex, sumatriptan, and/or 3-[2-(dimethylamino)ethyl]-N-methyl-indole�5-methanesulfonamide succinate (1:1)? anyone ever tried any of this or been on Imitrex(sumatriptan), and maybe taken too much? i'm guessing it's psychoactive and hallucinagenic but i can't accurately calculate a dose and i don't know the toxicity or any of that because the only available info on the net is incredably inconclusive.

as per your request.....
SUMATRIPTAN
CAUTIONS
ADVERSE REACTIONS
ADVERSE REACTIONS, CENTRAL NERVOUS SYS.
A. CENTRAL NERVOUS SYSTEM EFFECTS
1. In one study, SUMATRIPTAN 2 mg intravenously produced mild symptoms of pressure and heaviness in various parts of the body, mainly the head, in 60% of patients. Occasional feelings of tingling and warmth were also reported; symptoms resolved completely upon completion of the infusion (Doenicke et al, 1988).
2. One minute after receiving subcutaneous SUMATRIPTAN, a patient developed a dysphoric reaction, which was compared to marijuana intoxication, and the reaction lasted 3 hours (Backshi & Yan-Go , 1996).
3. Scalp tingling, sensations of warmth, LIGHTHEADEDNESS, and heavyheadedness have been reported after 2 mg SUMATRIPTAN intravenously or 100 mg orally (Fowler et al, 1989).
4. FATIGUE, DIZZINESS, and DROWSINESS have been reported (Prod Info Imitrex(R), 1997).
5. Rare reports of SEIZURES have occurred after administration of oral and subcutaneous sumatriptan (Prod Info Imitrex(R) injection, tablets, 2000).
3.3.4 ENDOCRINE/METABOLIC
A. ENDOCRINE EFFECTS
1. One small (n=6), randomized, placebo-controlled study performed with healthy volunteers found growth hormone secretion increased dramatically after SUMATRIPTAN administration compared to placebo, while no change in cortisol secretion was observed (Rolandi et al, 1992). The clinical significance of this effect is unknown.
3.3.5 GASTROINTESTINAL
A. GASTROINTESTINAL EFFECTS
1. A bad or unusual taste has been reported in 13% to 25% of over 1500 patients receiving intranasal sumatriptan (Prod Info Imitrex Nasal Spray(R), 2000).
2. Slight NAUSEA was seen in one patient after oral administration of 100 mg SUMATRIPTAN (Fowler et al, 1989). Children reported nausea and vomiting after intranasal use (Ueberall & Wenzel, 1999).
3. In healthy volunteers, sumatriptan administration significantly increased gastroesophageal reflux following a meal. This may be due to sumatriptan's ability to maintain relaxation of the lower esophageal sphincter associated with gastric distention following a meal. Caution is recommended when considering sumatriptan therapy in a patient with gastroesophageal reflux disease (Sifrim et al, 1999).
4. Five episodes of MESENTERIC ISCHEMIA have been reported in two women within hours of sumatriptan use that resolved following medical care and discontinuation of sumatriptan (Liu et al, 2000). A 45-year-old female sought medical attention following 4 episodes of abdominal pain and bloody diarrhea accompanied with hypotension. Medical history included migraine headaches, without aura, and chronic daily headache. All episodes abdominal symptoms occurred after administration of sumatriptan, up to ten 6-milligram (mg) doses per week, much higher than the recommended daily maximum dose. Once the patient was treated with emergency exploratory laparotomy and right hemicolectomy for transmural bowel necrosis. Thickening of the wall of the proximal jejunum was noted on computed tomography with another episode. Sumatriptan therapy was discontinued and for 14 months the patient remains symptom free; however, she has since experienced two additional episodes. The second patient was a 63-year-old female who experienced abdominal pain and bloody diarrhea within hours of taking sumatriptan 50 mg for migraine headache. Ischemic colitis was diagnosed and a mesenteric angiogram suggested vasospasm. Sumatriptan therapy was discontinued 4 months ago and the patient remained symptom free.
3.3.8 OCULAR
A. VISUAL CHANGES
1. Although the incidence is very low (1%), visual changes have been reported in patients receiving SUMATRIPTAN (Prod Info Imitrex(R) injection, tablets, 2000). Children reported photophobia after intranasal use (Ueberall & Wenzel, 1999).
3.3.9 RESPIRATORY
A. RESPIRATORY EFFECTS
1. Following nasal administration of 5, 10 or 20 mg sumatriptan, nose and throat irritation occurred in 5% of 3,378 patients. Symptoms were transient and resolved in less than 2 hours in most patients (Prod Info Imitrex Nasal Spray(R), 2000).
2. Reports of chest tightness in 3% to 5% of patients led to concern that SUMATRIPTAN might be responsible for induction of bronchospasm, and clinically, for exacerbation of asthma. The clinical database consisting of 75 clinical trials conducted by the manufacturer identified 375 asthma sufferers who were treated for 1214 episodes of migraine. Among these patients, six observed acute asthma exacerbations; only one of the six was clinically related to SUMATRIPTAN use (Prod Info Imitrex(R), 2000).
3. In light of these results, it is unlikely that chest tightness associated with SUMATRIPTAN use represents bronchospasm, but rather it is more likely to be related to pulmonary vasoconstriction.
3.3.10 SKIN
A. URTICARIA
1. After a year of subcutaneous and oral SUMATRIPTAN therapy, a patient developed URTICARIAL WHEALS on his palms, soles, and ankles 20 to 24 hours post administration. Thereafter, recurrence of symptoms with both dosage forms produced identical results (Anon, 1996). However, another patient developed a WHEAL and FLARE response following the second sumatripian injection but oral sumatripian did not cause any adverse effects and was well tolerated (Black & Caldwell, 1994).
B. PAIN ON INJECTION
1. Pain on injection was reported by all patients receiving SUMATRIPTAN 2 to 3 mg subcutaneously (Brion et al, 1989). In two large (combined n=1104), randomized, double-blind, placebo-controlled parallel group trials, the rates of injection site reaction reported in the placebo, single 6 mg SUMATRIPTAN injection, and double 6 mg SUMATRIPTAN injections groups were 24%, 59%, and 63%, respectively (Cady et al, 1991).
C. ANGIOEDEMA
1. Four cases of angioedema in association with SUMATRIPTAN use were reported to the Australian Adverse Drug Reactions Committee (Anon, 1993). Causality is unknown.
3.3.11 MUSCULOSKELETAL
A. MUSCULOSKELETAL EFFECTS
1. Chest, neck, or jaw tightness has been reported to occur in less than 5% of patients in controlled clinical trials (Prod Info Imitrex(R), 2000).
3.3.12 OTHER
A. OVERDOSE See POISINDEX(R) Management "SUMATRIPTAN AND RELATED AGENTS"
B. DEPENDENCE
1. A double-blind, placebo- and MORPHINE-controlled study was undertaken to determine abuse potential of subcutaneous SUMATRIPTAN in 12 male substance abusers (Sullivan et al, 1992). SUMATRIPTAN was psychoactive, could be discriminated from placebo, reduced euphoria scores, increased apathetic sedation scores, and lacked identification as a drug of abuse. Sumatriptan appears to have low abuse potential.
C. HYPERSENSITIVITY
1. In post-marketing experience, hypersensitivity to SUMATRIPTAN injection has been reported, including anaphylactoid reactions, rash, urticaria, pruritus, erythema and shortness of breath (Prod Info Imitrex(R), 2000).
3.4 TERATOGENICITY/EFFECTS IN PREGNANCY
A. TERATOGENICITY
1. U.S. Food and Drug Administration's Pregnancy Category C (Prod Info Imitrex(R), 2000).
See Drug Consult reference: "PREGNANCY RISK CATEGORIES"
2. Australian Drug Evaluation Committee's (ADEC) Category B3 (ADEC, 1996).




[This message has been edited by sckbch (edited 04-12-2001).]

I was prescribed zomig (migraine meds) then switched to imitrex. Never got high on any of em though. Don't really think you can.

can't get high from imitrex densegirl420? hello, i'm earth, have we met? did you not just read the fuckin post from sckbch?

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patient developed a dysphoric reaction, which was compared to marijuana intoxication, and the reaction lasted 3 hours

that was almost immedietly with an IV subcontinous, so if you took a large pill dose YOU'D GET FUCKIN HIGH MORON. its a fuckin TRYPTAMINE smartguy. ya know tikal- related to 5 Meo DMT and all that kinda stuff.

Slipwalker, just out of curiousity, I was wondering why you keep referring to me as a guy. I mean, do you know how to read? I'm just telling you that i took a bunch of imitrex and i didn't feel at all high off it so get your panties out your ass.

Oh and i love how you call me a teen when your still living with your parents, bragging about stealing their meds. At most, your only 22 and think you know something since you always got alot to say.

When will people learn that Slpwlker enjoys arguing with anyone who will retailiate if you dont he gets boored really quick and his Info seems to be good almost all the time so I dunno why peeps would wanna ditch such a nice active research gathering member.

If those meds get you a high you like and your willing to accept any possible negative side effects why not go 4 em man?

dankmoldycrevice- you never said you took an adequite dose to get high off of. its like lorazepam- you don't take a standard dose to feel it, but when you take the right amount it works, and it works well. i tried it. It is a tryptamine, which you probably have no idea what that is. I doubt you took extra imitrex just to see before my post. Who would have done that because anyone would have thought it would have been a simple shitty analgesic similar too ibuprofen or naproxen ESPECIALLY you. I mean i've read your "pharmie" crap and it's meritless gunk. I couldn't believe you actually wanted to argue that fuckin diazepam isn't the genric name for valium. You just have to be kidding. Basically in terms of your pharmaceutical knowledge you are a shitheel to me and i'd appreciate it if you got the fuck outta my post because it was intended for the responsibly pharmaceutically INTELLIGENT individual only and i wish i had a means to filter losers of your kind out with. Personally i think you should be sent to the barren pit asking and kerauni went to and your age only goes to show that whatever generation you are or pretend to be is a wasted one or you just happened to be a wasted portion. Like i've said in every other post that i've had to correct you in today, i think this is the fifth- do everyone a favor and just take what little dignity i left you with and go while you still have any left if you even do anymore.