Yours is more reliable then mine. So I might be wrong.

OP: aim me at disturbinstaticx

Well i took one of the 50mg last night, started feeling it around a half hour to an hour later. It was alright, laying down was the best. I can't for the life of rememeber if i even slept or not or just laid there all night feeling very relaxed. I definetly wasn't nodding like i would on heroin. Woke up today and am still feeling it a little since i just popped the whole capsule last night and didnt break the time release.

You still want me to aim you Aces?

Oh, and I misspelled Kadian in the title, but I think you all knew what I meant.

No he shouldnt. The small gain in bioavail would not even matter. It is not worth it to shove an enema up your ass for like a 5-10% gain. The same gain could be achieved with an enzyme inhibitor.

I will say this once again as i have said it atleast 20 times. The ONLY time rectal administration is used in a medical situation is if the patient cannot keep their stomach contents down. so go ahead and shove stuff up your ass if you want.

No he shouldnt. The small gain in bioavail would not even matter. It is not worth it to shove an enema up your ass for like a 5-10% gain. The same gain could be achieved with an enzyme inhibitor.

I will say this once again as i have said it atleast 20 times. The ONLY time rectal administration is used in a medical situation is if the patient cannot keep their stomach contents down. so go ahead and shove stuff up your ass if you want.

Not if you adjust the pH of the solution to between 7 and 8. When the pH is adjusted like this the bioavailability and peak plasma concentration both double.



And yeah, legituser aim me.

yeah i knew what he meant right away though

why did you ask to cut your dose of morphine almost in half meta

whats so much better about ms contin i never really noticed a difference in morphine except for ir morphine

yeah i knew what he meant right away though

why did you ask to cut your dose of morphine almost in half meta

whats so much better about ms contin i never really noticed a difference in morphine except for ir morphine

morphine is just as bad as codeine if you ask me

get some vicodin , oxy , hydromorphone , or just quick fucking procrastinating and hit up the heroin already.

kadians are awesome to shoot up the trick is to crush the beads the best you can and use warm water DO NOT put fire under your spoon the beads are wax based. instead push them around in the spoon with the end to your needle the water will turn cloudy. then a bit of cotton and your ready.

Not if you adjust the pH of the solution to between 7 and 8. When the pH is adjusted like this the bioavailability and peak plasma concentration both double.



And yeah, legituser aim me.

source?

source?

Moolenaar, F., Yska, J., P., Visser, J., & Meijer, D., K., F., (1985) Drastic improvement in the rectal absorption profile of morphine in man. European Journal of Clinical Pharmacology, Vol 29 pages 119-121.

Moolenaar, F., Yska, J., P., Visser, J., & Meijer, D., K., F., (1985) Drastic improvement in the rectal absorption profile of morphine in man. European Journal of Clinical Pharmacology, Vol 29 pages 119-121.

No i would like to see something online that states what you said not the book source.


I didn't read this whole thread so...

I don't know if this is a new form of morphine or - as I suspect - you misspelled: Kadian.

If it's Kadian, I wouldn't think it a great deal.

First of all, morphine is good with pain, but not that great for recreation [compared to other shit out there, that is].

Second of all, Kadian itself kinda sucks. I was on 100mg Kadians a few years ago and I asked to be put back on 60mg MS-Contin.

Kadian was fine for me. I used it for a whole year and it got me nice and high and it was very recreational. i used it with the beads crushed and also not crushed. i would certainly rather have 100mgs of kadian over 60 of ms contin.

No i would like to see something online that states what you said not the book source.


Thats not a book, its a peer reviewed journal. That means the article has been subjected to the most rigorous academic standards and passed before publication.

And really man you care so much but couldnt fucking google the title of the article yourself?

http://www.springerlink.com/content/j606n384v5746640/

Thats not a book, its a peer reviewed journal. That means the article has been subjected to the most rigorous academic standards and passed before publication.

And really man you care so much but couldnt fucking google the title of the article yourself?

http://www.springerlink.com/content/j606n384v5746640/

Really man, YOU COULD FUCKING POST IT WHEN I ASKED YOU THE FIRST TIME. DICK

And that fails BECAUSE IT IS FOR MORPHINE HCL. sulfate is different. all morphine in painkiller form that i know of is morphine sulfate.

And I fail, BECAUSE IT IS FOR MORPHINE HCL. sulfate is different. all morphine in painkiller form that i know of is morphine sulfate.

simply extract and convert to hcl:

1) Dissolve crushed pills in water
2) Slowly add little drops of an NaOH solution until the water reaches pH 9. Be sure not to add too much, because then the extraction fails and nothing happens.
3) At pH 9 crystals should fall off, forming a clowd in the water. Put the glass in the freezer for about 10mins and filter out the crystals after that.

What you now have is pure morphine freebase. Changing to HCl salt is easy, too:

1) Dissolve in anhydrous (99%) alcohol.
2) Add 1ml of HCl and shake.
3) Let the alcohol evaporate (do NOT boil!) and you'll have some nice morphine hcl crystals.
4) Have fun.

Really man, YOU COULD FUCKING POST IT WHEN I ASKED YOU THE FIRST TIME. DICK

And that fails BECAUSE IT IS FOR MORPHINE HCL. sulfate is different. all morphine in painkiller form that i know of is morphine sulfate.

They are two different chemicals but there is no know difference in their gastro-intestinal absorbtion. And before you ibtch that you're too lazy to google again, here you go.

http://www.ncbi.nlm.nih.gov/pubmed/18076801

How much more data am i going to have to spoon feed you? This time dont come back until you have your own article bcking what you have to say as im tired of having to disprove your conjecture.

They are two different chemicals but there is no know difference in their gastro-intestinal absorbtion. And before you ibtch that you're too lazy to google again, here you go.

http://www.ncbi.nlm.nih.gov/pubmed/18076801

How much more data am i going to have to spoon feed you? This time dont come back until you have your own article bcking what you have to say as im tired of having to disprove your conjecture.
Spoon feed me. God your a douche bag. All I wanted was a LINK the FIRST FUCKING TIME I ASKED YOU ASSHOLE. jesus.
from your link.
"BACKGROUND & OBJECTIVE: Morphine sulfate controlled-released tablet and morphine hydrochloride sustained-released tablet are preferred medicines for treating moderate-severe cancer pain. There are some differences between the two medicines in their efficacy, metabolism and adverse events. "

"CONCLUSIONS:Both morphine sulfate controlled-released tablet and morphine hydrochloride sustained-released tablet are safety in treating moderate-severe cancer pain and the toxicities are tolerable. We recommend to take morphine sulfate controlled-released tablet for older patients and the patients with digestive disorders."
dude that really proves alot. that has nothing to do with rectal absorbtion of the two forms of morphine.

my turn:
www.springerlink.com/content/v0h25846756r46v1/
"Summary Sustained-release morphine (MST) given by the rectal route was compared with oral MST in an open randomised cross-over trial in ten patients with cancer who received stable doses of MST. NO SIGNIFICANT DIFFERENCE was found in the areas under the curve of the concentration-time profiles (AUC) following oral or rectal administration for parent morphine. The "
"These findings suggest slower absorption but less first-pass metabolism of MST after rectal administration. No significant difference was noted between the oral and the rectal route in measurements on visual-analogue scales for pain or side effects. We recommend the rectal route as being suitable for MST administration when the oral route is no longer available. In changing from oral to rectal administration, the same dose and dose interval may be used, but dose adjustment may be needed"

Less first pass metab but that is not necessarily true for everyone. but much slower absorbtion anyway, meaning if you dont want to wait a few hours for your morphine to kick in you should just pop it. Note the second to last sentence:"We recommend the rectal route as being suitable for MST administration when the oral route is no longer available." so enjoy shoving shit up your ass fag.

my turn:
www.springerlink.com/content/v0h25846756r46v1/
"Summary Sustained-release morphine (MST) given by the rectal route was compared with oral MST in an open randomised cross-over trial in ten patients with cancer who received stable doses of MST. NO SIGNIFICANT DIFFERENCE was found in the areas under the curve of the concentration-time profiles (AUC) following oral or rectal administration for parent morphine. The "
"These findings suggest slower absorption but less first-pass metabolism of MST after rectal administration. No significant difference was noted between the oral and the rectal route in measurements on visual-analogue scales for pain or side effects. We recommend the rectal route as being suitable for MST administration when the oral route is no longer available. In changing from oral to rectal administration, the same dose and dose interval may be used, but dose adjustment may be needed"

Less first pass metab but that is not necessarily true for every. Note the second to last sentence:"We recommend the rectal route as being suitable for MST administration when the oral route is no longer available." so enjoy shoving shit up your ass fag.

Maybe i was being ruder than was warranted, sorry. But im kinda frustrated by the fact that you were too lazy to search for the first source after i posted all the information needed to find it.

Then you try to disagree with the findings based on no scientific evidence, just the speculation that they might not be valid. This forces me do go through and review more literature so that i can point out the flaw in your argument, again.

Now, you link an article that says that there is a difference between oral and rectal morphine doseage. We already know this. Thats the whole point of this discussion. What you need is an article examining the difference between the absorption of morphine hcl and morphine sulfate.

That would be the article i posted, which shows that there is no significant difference in gastro-intestinal absorption of the two. Hence no reason to assume that the findings in my original atricle would not be applicable to morphine sulfate.

So, once again, sorry i was rude, but you are making me spoon feed you info and pissing me off

Maybe i was being ruder than was warranted, sorry. But im kinda frustrated by the fact that you were too lazy to search for the first source after i posted all the information needed to find it.

Then you try to disagree with the findings based on no scientific evidence, just the speculation that they might not be valid. This forces me do go through and review more literature so that i can point out the flaw in your argument, again.

Now, you link an article that says that there is a difference between oral and rectal morphine doseage. We already know this. Thats the whole point of this discussion. What you need is an article examining the difference between the absorption of morphine hcl and morphine sulfate.

That would be the article i posted, which shows that there is no significant difference in gastro-intestinal absorption of the two. Hence no reason to assume that the findings in my original atricle would not be applicable to morphine sulfate.

So, once again, sorry i was rude, but you are making me spoon feed you info and pissing me off

its cool. my bad also. but my point was that it is not suggested unless the oral route is unavailible. If you want to shoot enemas in your pooper that is fine i guess. But it really is not necessary. you can get just as good effects from oral use. if it was so much better rectally then ALL formulations would be for rectal administration. The effects take longer to kick in rectally. Seriously thoughi am going to folow medical advice on that and I would only use rectal admin if it was a last resort as it is suggested. Also every biavaibility chart i have seen on morphine groups rectal and oral together wtih the same percentage of bioavail.Also every person has sligthly different absorbtion rates so what has a higher bioavailbility for you rectally may not be the same or the next person. Anyway my bad for also getting all mad over nothing.
i wasnt making you spoon feed me man i was just originally asking for the article maybe since i said source you thought i just wanted the citation but I actually wanted to see the literature on it not the citation.