Does anyone know what the LD-50 of Salvinorin A is? or at what point it may pose problems?

Very high. Of course, too much of it will cause some mental issues and all that fun stuff, but the actual lethal dose is far beyond what any normal person could ingest without getting sick and/or too fried to even be able to do it.

Assuming you're not trying to kill yourself by overdosing on it, it's not going to happen.

edit:


Q: Can you take a fatal overdose?

A: No case of fatal salvinorin poisoning has been reported. The human oral lethal dose is not known but is believed to be extremely high. Leander Valdes, III provided the following information for inclusion in this FAQ regarding acute toxicity studies in mice: "I tested Salvinorin A intraperitoneally in mice at very high doses and it appeared to be not very toxic. This was long before the compound was being taken orally and it was testing about as potent as mescaline in the assay I was using. In light of the extreme potency of the compound, I think it quite possible and probably very likely that it was not being well absorbed. I had it in a mix of corn oil, tween 80 (a fancy emulsifier) and water. Dissolving the compound in solvents such as ethanol, acetone or DMSO probably delivers quite a bit more drug to the body (I didn't use them because I wanted an inactive vehicle). "

Swallowed salvinorin is not well absorbed. The chances of inadvertently swallowing a lethal overdose of an oral preparation of leaves, slurry or elixir are extremely low.

If salvinorin is inhaled as multiple inhalations of leaf smoke or vapor one could reasonably expect to pass out before he/she could take a lethal overdose. But significantly, nothing is known about the toxic effects of smoking truly massive 'single bolus' doses of pure salvinorin, such a practice might be quite dangerous, and should certainly be avoided.

Although fatal poisoning from Salvia divinorum appears to be very unlikely to occur; there is another type of lethal overdose --- one that kills not by poisoning but by impairing judgment and survival instincts and causing fatal injury. If you smoked salvinorin and then walked out of a ten story window you would be very dead indeed. That's why sitters are needed when smoking or vaporizing high doses.

http://www.sagewisdom.org/faq.html

Ok i figured it was pretty safe, I ask because i plan on making a drink/tincture. If i put 1 gram of standardized 36mg Salvinorin A into a bottle of Bacardi 151 75.5% alc (750ml) what would an active dose be? Will swallowing it even be effective?
Thanks,

http://www.erowid.org/experiences/exp.php?ID=3425

http://www.erowid.org/plants/salvia/salvia_extraction4.shtml

those are sublingual tinctures, im interested in oral ingestion

you're not gonna get any effects from drinking it.

dr. phil is a liar.

I believe I read somewhere, probably Sage Wisdom or Erowid, that one of the traditional ways to use it is making a SHITLOAD of tea. So it might work.

It most certainly will work -- it just takes a bit more and isn't nearly as efficient.

Infusion - Most ethnographic accounts state that the Mazatecs make an infusion by rubbing leaves together and squeezing the leaf-juice into water. A couple of reports state that the leaves were first crushed on a metate (a flat stone). One ethnographic report described the preparation of a dose by merely piling up the leaves in pairs, face to face, and then rolling them into a cigar-shaped bundle, chewed, and swallowed (Blosser 1991–1993 in Ott 1999). Unfortunately, as far as a 'dose' goes, the available ethnographic data usually relates the number of leaves used per dose (frequently stated as so many 'pairs' of leaves, due to the Mazatec penchant for counting them in this manner). Such information may not be too useful because leaves can vary quite a bit in size, with some leaves being five or more times the size of others, depending on growing conditions, and the potency of leaves is believed to vary dramatically from plant to plant.

With regard to infusions, the number of leaves used to prepare a single dose reported in the ethnographic literature has ranged from 6 to 240 (Ott 1995). One paper (Ott 1999) described two doses as being a "large double-handful of leaves (plant tops, stems and all)", and another paper mentions using 20 to 80 or more pairs of leaves, helpfully also gave the weight of the fresh leaves as being about 50 to about 200 grams (Valdés et al. 1983).

Contemporary studies into the chemistry and pharmacology of Salvia divinorum have discovered that the traditional infusion preparation is perhaps the least efficient method of consuming the plant. The plant's active chemistry is not soluble in water, and it is speculated that it may be partially deactivated via the stomach. Comparatively larger amounts need to be consumed, if it is taken this way. On the other hand, effects—which begin after about 15 minutes (Valdés et al. 1983, Ott 1999)—may last longer than via other routes of ingestion; over 2.5 hours in one report (Valdés et al. 1983), and up to 3 hours 20 minutes in another case (Ott 1999).


http://www.erowid.org/plants/salvia/salvia_faq.shtml#methods

true, but very inefficient.

now, was the op talking about 1 gram extract or 36mg pure salvinorin A?

The point at which it may cause problems doesn't have anything to do with the point at which you are 50% likely to die.....

let us know how it goes:D