This is probably a really stupid question. But what the hell, I'll ask anyway.

Is there a way a normal person, without in-depth knowledge of chemistry, synthesise LSD?

If so what reagents would you need and such. I know what you're all thinking, but I am only curious. I have no intention of making LSD.

This is probably a really stupid question. But what the hell, I'll ask anyway.

Is there a way a normal person, without in-depth knowledge of chemistry, synthesise LSD?



In short, no. The knowledge and reagents that are required can be both difficult to grasp and acquire.

Start studying.

http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml

SYNTHESIS : A solution of 6.7 g KOH in 100 mL H2O, under an inert atmosphere and magnetically stirred, was brought to 75 °C, and 10 g ergotamine tartrate (ET) added. The reaction mixture turned yellow as the ergotamine went into solution over the course of 1 h. The stirring was continued for an additional 3 h. The reaction mixture was cooled to about 10 °C with an external ice bath, and acidified to a pH of about 3.0 by the dropwise addition of 2.5 N H2SO4. White solids started to appear early in the neutralization; approximately 60 mL of sulfuric acid was required. The reaction mixture was cooled overnight, the solids removed by filtration, and the filter cake washed with 10 mL Et2O. The dry solids were transferred to a beaker, suspended in 50 mL 15 % ammonia in anhydrous ethanol, stirred for 1 h, and separated by decantation. This extraction was repeated, and the original decantation and the second extract combined and filtered to remove a few hundred milligrams of unwanted solids. The clear filtrate was stripped of solvent under vacuum, the residual solids dissolved in 50 mL of 1% aqueous ammonia, and this solution was acidified as before with 2.5 N H2SO4. The precipitated solids were removed by filtration and washed with Et2O until free of color. After drying under vacuum to a constant weight, there was obtained 3.5 g of d-lysergic acid hydrate, which should be stored in a dark, sealed container.

A suspension of 3.15 g d-lysergic acid hydrate and 7.1 g of diethylamine in 150 mL CHCl3 was brought to reflux with stirring. With the external heating removed, there was added 3.4 g POCl3 over the course of 2 min, at a rate sufficient to maintain refluxing conditions. The mixture was held at reflux for an additional 5 min, at which point everything had gone into solution. After returning to room temperature, the solution was added to 200 mL of 1 N NH4OH. The phases were separated, the organic phase dried over anhydrous MgSO4, filtered, and the solvent removed under vacuum. The residue was chromatographed over alumina with elution employing a 3:1 C6H6/CHCl3 mixture, and the collected fraction stripped of solvent under hard vacuum to a constant weight. This free-base solid can be recrystallized from benzene to give white crystals with a melting point of 87-92 °C. IR (in cm-1): 750, 776, 850, 937 and 996, with the carbonyl at 1631. The mass spectrum of the free base has a strong parent peak at mass 323, with sizable fragments at masses of 181, 196, 207 and 221.

This base was dissolved in warm, dry MeOH, using 4 mL per g of product. There was then added dry d-tartaric acid (0.232 g per g of LSD base), and the clear warm solution treated with Et2O dropwise until the cloudiness did not dispel on continued stirring. This opaqueness set to a fine crystalline suspension (this is achieved more quickly with seeding) and the solution allowed to crystallize overnight in the refrigerator. Ambient light should be severely restricted during these procedures. The product was removed by filtration, washed sparingly with cold methanol, with a cold 1:1 MeOH/Et2O mixture, and then dried to constant weight. The white crystalline product was lysergic acid diethylamide tartrate with two molecules of methanol of crystallization, with a mp of about 200 °C with decomposition, and weighed 3.11 g (66%). Repeated recrystallizations from methanol produced a product that became progressively less soluble, and eventually virtually insoluble, as the purity increased. A totally pure salt, when dry and when shaken in the dark, will emit small flashes of white light.

DOSAGE : 60 to 200 micrograms, orally

DURATION : 8 - 12 hrs

http://www.drugs-forum.com/chemistry/chemistry/paspalic.lysergic.html

130 g of paspalic acid are added rapidly to 780.1 g of a 40% strength solution of tetrabutylammonium hydroxide in water, with stirring and under a stream of nitrogen. The mixture is brought to 30±2°C. and allowed to react at this temperature for 20 hours. The reaction medium is cooled to about 20°C and held at this temperature for 3.5 h 918 g of water are added, followed by acidification using 95% strength sulphuric acid until the pH is 3.5, while maintaining the temperature at about 30°C. The reaction mixture is then cooled to 10±2°C. and held at this temperature for 30 minutes. The mixture is filtered through a sinter funnel under a vacuum of 0.4 bar, washed with 3x300 ml of water and then dried for 14 h at 75±2°C and 20 mbar. This gives 107 g of lysergic acid comprising less than 3% of isolysergic acid and the yield (weight/weight) is 80%.

There you go.

Oh, and that took one search on google.

There you go.

Oh, and that took one search on google.

Maybe I didn't want to use google....




It killed my father, and raped my mother. /sobstory

Your mother liked it.

Your mother liked it.

That might be true. And the fact he paid for it.... it just hardens the fact that it was rape.

Maybe I didn't want to use google....






If you can't figure out google, good luck manufacturing LSD.

I somehow doubt that every person that makes LSD is a distinguished chemist. Still, seems like it'd be close to impossible to do under normal circumstances

Get the fuck out.

If you can't figure out google, good luck manufacturing LSD.

This^^. Google anything on synthing acid and you'll find plenty of sites that say you need mad knowledge in organic chemistry as well as a shitload of lab equipment.

I wonder how many chemists their are that are smart enough to make LSD and make some for themselves. It seems like the people who would know how wouldn't be the ones to enjoy it.

You are going to die setting up a Bunsen burner. But, in all seriousness you probably won't be able to get very good quality or any lsd from a amateur synth

This is probably a really stupid question.

Yeah, it's up there on the stupid-o-meter.

Is there a way a normal person, without in-depth knowledge of chemistry, synthesise LSD?

No. It can be difficult even for people with that kind of knowledge.

Maybe I didn't want to use google....

God forbid you get an answer almost instantaneously rather then asking a message board (that has seen this question dozens of times, mind you) where you won't get the answer right away and/or will get flamed.

I wonder how many chemists there are that are smart enough to make LSD and make some for themselves. It seems like the people who would know how wouldn't be the ones to enjoy it.

See:

Albert Hofmann
Owsley "Bear" Stanley
William Pickard
Clyde Apperson
Alexander Shulgin
Any of the cooks associated with the rainbow family/the dead family

Exactly.

I'm sure a shit load of people can make it they just don't want to. I'm no chemistry expert but I'm sure anyone who's earned a legitimate degree in the required field of chemistry could get the job done if they had access to the chemicals and supplies [knowledge doesn't give you the physical shit you need].

Albert Hofmann
Owsley "Bear" Stanley
William Pickard
Clyde Apperson
Alexander Shulgin
Any of the cooks associated with the rainbow family/the dead family

I've only heard of Albert Hofmann, but that's not a huge number of chemists. Sure their are chemists that do make it (and probably lots of them) but compared with the people who have the knowledge and equipment its probably a small ratio. I'm just guessing it would be interesting if they did some sort of survey.

I've only heard of Albert Hofmann, but that's not a huge number of chemists. Sure their are chemists that do make it (and probably lots of them) but compared with the people who have the knowledge and equipment its probably a small ratio. I'm just guessing it would be interesting if they did some sort of survey.

Ever take into account the fact that it's illegal and many chemists do not want to risk prison by making it?

Albert Hofmann
Alexander Shulgin, hes discovered more psychs and done more of them than pretty much any living person....

Pickard and Apperson were arrested in 2000, they supplied about 1/3 of the lsd produced in the country.... according to Wikipedia pickard was very likely part of the brotherhood of eternal love, yea he was doing lsd... that one bust apparently knocked LSD's availability down by 95% due to other chemist stopping production after the two were arrested....

But LSD production is one of those things where its just go big or go home, if you have the precursors, the lab, and people buying it by the gram you could get very very rich in a very short amount of time.... 25 kilos of ergotamine tartrate could be made into around 5 kilos of LSD. that would be 50,000 100ug hits.... and that is more than most are laid nowadays... a single person could supply the majority of the country.

I highly doubt it's nearly as high as 95%. The DEA just likes throwing out high numbers so the rest of the country thinks they're doing a super fantabulous job.

It's still flowing heavily throughout the country and, from what I can tell, has been growing in popularity.

New people do pop up. You seriously think someone didn't take Pickard's place? You could be right, but with the nature of LSD I would be willing to believe that figure.

Benadryl, just market that shit... Without da labelz
:D

25 kilos of ergotamine tartrate could be made into around 5 kilos of LSD. that would be 50,000 100ug hits....

ug = one millionth of a gram, no?

That means, at 100ug per hit.....

10000 hits per gram

and with 1000 grams per kilo

5 kilos = 5000 grams

5000 x 10000 = 50,000,000

But LSD production is one of those things where its just go big or go home, if you have the precursors, the lab, and people buying it by the gram you could get very very rich in a very short amount of time.... 25 kilos of ergotamine tartrate could be made into around 5 kilos of LSD. that would be 50,000 100ug hits.... and that is more than most are laid nowadays... a single person could supply the majority of the country.

This is basically what I've been told. Pretty cool that all the acid is made by just a few people in the US. It seems like it would be easier to mass produce in other countries and then transport it to the states (or maybe thats what they do) since its relatively small and doesn't smell.

I REALLY want to try lsd now. But will probably have to wait until college when it will be easier to find and use.