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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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 #1 
Old 2008-11-08, 03:24
2CapsOfDateRape 2CapsOfDateRape is offline
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Default 5HTP, MDMA and seratonin syndrome.

It is considered harm reduction to take 5HTP (an amino acid precurser to seratonin) before and after rolling on ecstasy. The theory is that MDMA depletes seratonin and 5HTP will replenish it.

Combining large amounts of ecstasy and SSRIs will lead to seratonin syndrome. The bottle of 5HTP I possess says to not combine with SSRIs.

Doesn't this naturally imply that combining 5HTP and MDMA will produce at best damage to seratonin receptora and at worst seratonin syndrome?
 #2 
Old 2008-11-08, 03:39
spl1ff spl1ff is offline
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Default Re: 5HTP, MDMA and seratonin syndrome.

yes, it increases serotinin, but not to the point of serotonin syndrome
 #3 
Old 2008-11-09, 23:12
rtb91 rtb91 is offline
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Default Re: 5HTP, MDMA and seratonin syndrome.

SSRI's only prevent axon death, not serotonin syndrome. 5htp should be used after a roll (about 9 hours) to ease the comedown.

Some findings suggest grapefruit juice contains an enzyme inhibitor that can reduce toxic metabolites and improve the high. However, there has not been enough research to prove this.
 
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