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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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  #1   Add jonogt to your ignore list  
Old 2008-10-28, 16:00
jonogt jonogt is offline
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Default Why do opiates get harder to quit as your dose gets lower?

The title probably makes me look like an idiot... I know that if your taking say, 10 units [of whatever] a day and you cut it to 2 immediately, your not gonna be a happy camper. What I'm talking about is if your taking 10 units a day, and you reduce it by small amounts each day, why it gets harder as you approach zero.

In the back of my head I always thought it nonsense and not possible, but I went n' got myself addicted to opium 'tea' over the last few months. It's not severe and doesn't compare to quitting oxycodone, but it is there. I tried just dropping it on a moments notice a month or so back, and it kept me up almost 2 straight nights tossing and turning with leg pain, along with mild flu-like symptoms and irritability.

Anywho, the point is that I've been tapering my dose each day in hopes of being done drinking this stuff so routinely. When I recognized that I was a mild/moderate addict I was drinking tea of about 8g of powder a day. I cut that down to 4.5g the next day, and 3g the day after that, and really wasn't feeling a lot of discomfort. I've been sitting at 2.5 now for a couple days straight. I still get a pretty solid 2 hour buzz right after drinking it, but about 22 hours after consuming I can really start to tell that I'm missing something, but if I go back up to 3.5 then everything feels fine.

Can anyone explain the chemistry of this? Why does the body react more to cutting out 1 gram than it does to cutting out 3.5? I thought maybe its the portion of your total dose that your removing, but 3.5 to 2.5 is a smaller fractional decrease than 8 to 4.5, and I'm feeling the strain of 3.5 to 2.5 more after several days of acclimation than I did the 8 to 4.5 in an overnight change.

I've heard this is how it works before from someone who gets methadone pink drink from a clinic, and it seemed very odd to me then, and it still seems odd to me now.

Any vets care to comment?
-Jon
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  #2   Add vilbe to your ignore list  
Old 2008-10-28, 16:35
vilbe vilbe is offline
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Connecticut Send a message via AIM to vilbe
Default Re: Why do opiates get harder to quit as your dose gets lower?

the ones that involve needles get harder as you shoot less...


but to make this relevent. you've gone from continously flooding your receptors to just turning some of them on, after being used to all of them being turned on. being artificial [ie not body produced] you've stopped producing natural endorphins, because why bother, its been flooded it didn't need to. the cause of hurt is your body realizing oh shit i've been getting lazy...

from here on in cut in .5 grams maybe?
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  #3   Add Metaphysicist to your ignore list  
Old 2008-10-28, 16:47
Metaphysicist Metaphysicist is offline
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Sebastopol CA
Default Re: Why do opiates get harder to quit as your dose gets lower?

Well, assuming that you aren't cutting down too fast and are getting w/d's, then it is a mental thing. You realize that you are getting closer to the point where you won't be taking any anymore.

At least that's how it was with me.
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  #4   Add ilovechronic to your ignore list  
Old 2008-10-28, 20:09
ilovechronic ilovechronic is offline
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Default Re: Why do opiates get harder to quit as your dose gets lower?

Maybe your not taking long enough to stablize on the last higher dose. jumping down 1 gram is a alot to jump.
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