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Laboratory Tips Safety proceedures, test reagents, drilling rubber stoppers, bending glass tubes, etc. Contributed to by chemists.

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 #1 
Old 2008-10-26, 06:45
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Default Mephedrone synthesis?

I cant find this anywhere. Yet there are a good 4-6 suppliers of it.

4-methylmethcathinone=mephedrone..maybe it can be made from mcat?
 #2 
Old 2008-10-26, 22:03
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Default Re: Mephedrone synthesis?

4-methylmethcathinone=mephedrone..maybe it can be made from mcat?

...and you spent the last year or two trying to figure out the 2Cs?

Yes. It can be made from MCat. Pretty easily, except that bitchin' amine-protection you've got to attempt.

Alternately, one can use toluene as a benzene analog...
 #3 
Old 2008-10-27, 06:36
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Default Re: Mephedrone synthesis?

I do not like psychedelics any moar...

"one can use toulene as a benzene analogue"

Does this mean that I will get mephedrone or an analogue of mephedrone?
 #4 
Old 2008-10-28, 00:16
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Default Re: Mephedrone synthesis?

Does this mean that I will get mephedrone or an analogue of mephedrone?

I don't know. Does mephedrone have a methyl group on the ring like toluene, or a bare ring like benzene?
 #5 
Old 2008-10-28, 08:18
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Default Re: Mephedrone synthesis?

Mephedrone has a methyl group on the ring, like toulene:
http://www.erowid.org/chemicals/show_molecule.php?i=4_methylmethcathinone/4_methylmethcathinone_2d.gif

I don't get what your hinting at.
 #6 
Old 2008-11-11, 03:03
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Utah: Mountains, Mormons, Meth
Default Re: Mephedrone synthesis?

Quote:
Originally Posted by TheBlackPope
Mephedrone has a methyl group on the ring, like toulene:
http://www.erowid.org/chemicals/show_molecule.php?i=4_methylmethcathinone/4_methylmethcathinone_2d.gif

I don't get what your hinting at.


Typically, total syntheses of methcathinone start with benzene. JP suggests that you start with toluene instead and p-alkylate it somehow (though I'm sure there's a way to do it).
 #7 
Old 2008-11-11, 08:21
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Default Re: Mephedrone synthesis?

JP suggests that you start with toluene instead and p-alkylate it somehow (though I'm sure there's a way to do it).

Ideally, the easiest way would probably be friedel-crafts addition of a haloethanoic acid to the benzene (toluene), followed by alpha rehalogenation, lead acetate distillation, and a reactive metal hydroxide wash, in some order, to yield the corresponding 4-methyl-P-1-ol-2-propanone.

If someone doesn't know what to do with p2p, that's their problem... ;)
 #8 
Old 2008-11-11, 14:02
stateofhack stateofhack is offline
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Default Re: Mephedrone synthesis?

If someone doesn't know what to do with p2p, that's their problem... ;)

Egg and bacon sandwich?
 #9 
Old 2008-11-11, 16:22
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Utah: Mountains, Mormons, Meth
Default Re: Mephedrone synthesis?

Ideally, the easiest way would probably be friedel-crafts addition of a haloethanoic acid to the benzene (toluene), followed by alpha rehalogenation, lead acetate distillation, and a reactive metal hydroxide wash, in some order, to yield the corresponding 4-methyl-P-1-ol-2-propanone.

My only concern with this would be o-alkylation and the difficluty in separating those two out.
 #10 
Old 2008-11-23, 19:14
miceo miceo is offline
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Default Re: Mephedrone synthesis?

IIRC Mephedrone is also known as metacathinone, which synthesis is piss easy, you need practically zero anything to make it. Using such exotic chemicals like NaOH, HCl, pseudoepehedrine, KMnO4 and IPA. :D
 #11 
Old 2008-11-23, 19:34
fcknut fcknut is offline
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Default Re: Mephedrone synthesis?

Quote:
Originally Posted by miceo
IIRC Mephedrone is also known as metacathinone, which synthesis is piss easy, you need practically zero anything to make it. Using such exotic chemicals like NaOH, HCl, pseudoepehedrine, KMnO4 and IPA. :D


It's 4-methyl methcathinone (http://en.wikipedia.org/wiki/4-Methylmethcathinone), hence the talk of toluene...
 
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