Re: at what temperature does LSD begin to degrade
substance: lysergic acid diethylamide
trade names/synonyms:ergoline-8-carboxamide,9,10-didehydro-n,n-diethyl-6-methyl-, (8beta)-;9,10-didehydro-n,n-diethyl-6-methylergoline-8-carboxamide;
ergoline-8(beta)-carboxamide, 9,10-didehydro-n,n-diethyl-6-methyl-;
9,10-didehydro-n,n-diethyl-6-methylergoline-8(beta)-carboxamide; delysid;
n,n-diethyllysergamide; d-lsd; lsd-25; lsd; lsd (alkaloid); (+)-lsd;
d-lysergic acid diethylamide; lysergide; acid; blotter acid; window panes;
25; blue dots; the beast; c20h25n3o; ohs13028
chemical family:alkaloid
molecular formula: c20-h25-n3-o
molecular weight: 323.48
cercla ratings (scale 0-3): Health=3 fire=1 reactivity=0 persistence=3
nfpa ratings (scale 0-4): Health=3 fire=1 reactivity=0
------------------------------------------------------------------------------
components and contaminants
component: lysergic acid diethylamide percent: 100cas# 50-37-3
other contaminants: none
exposure limits:no occupational exposure limits established by osha, acgih, or niosh.
------------------------------------------------------------------------------
physical data
description: Tasteless, colorless and odorless crystalline solid.
melting point: 176-185 f (80-85 c)
specific gravity: not available
solubility in water: soluble
solvent solubility: soluble in benzene.
------------------------------------------------------------------------------
fire and explosion data
slight fire hazard when exposed to heat or flame.
Firefighting media:dry chemical, carbon dioxide, water spray or regular foam(1990 emergency response guidebook, dot p 5800.5).
For larger fires, use water spray, fog or regular foam
(1990 emergency response guidebook, dot p 5800.5).
firefighting:move container from fire area if you can do it without risk (1990 emergencyresponse guidebook, dot p 5800.5, guide page 53).
Extinguish using agent suitable for type of surrounding fire. Avoid breathing vapors and dusts. Keep upwind.
------------------------------------------------------------------------------
toxicity
lysergic acid diethylamide:
700 ng/kg oral-human tdlo; 2857 ng/kg oral-human tdlo; 857 ng/kg oral-human
tdlo; 750 ng/kg intramuscular-human tdlo; 16 mg/kg intravenous-rat ld50;
50 mg/kg intraperitoneal-mouse ld50; 46 mg/kg intravenous-mouse ld50; 300
ug/kg intravenous-rabbit ld50; 16 mg/kg subcutaneous-guinea pig ld50;
1800 ug/kg oral-wild bird ld50; mutagenic effects data (rtecs); reproductive
effects data (rtecs).
carcinogen status: none.
Lysergic acid diethylamide is toxic parenterally. Poisoning due to
psychotomimetic agents may affect the central nervous system. Persons with emotional disturbances or organic brain disease may be at increased risk from exposure. Cross tolerance between different psychotomimetic agents may occur.interactions with medications have been reported.
------------------------------------------------------------------------------
health effects and first aid
inhalation:
lysergic acid diethylamide:acute exposure- inhalation may cause systemic poisoning as detailed in acute ingestion.
chronic exposure- repeated exposure may cause systemic poisoning as detailedin chronic ingestion.
first aid- remove from exposure area to fresh air immediately. If breathing has stopped, perform artificial respiration. Keep person warm and at rest.treat symptomatically and supportively. Get medical attention immediately.
skin contact:
lysergic acid diethylamide:
Acute exposure- trip balls
chronic exposure- no data available.
ingestion:
lysergic acid diethylamide:
acute exposure- ingestion of psychotomimetic agents may cause nausea,vomiting, occasional diarrhea, sweating, headache, hypertension,
tachycardia, twitching, hyperreflexia, tremors and incoordination.
Bilaterally dilated and reactive pupils, nystagmus, and photophobia may
occur. Vasodilation, hypotension and respiratory depression may occur
at doses of 20-60 mg/kg. Bradycardia may be present at higher doses.
Convulsions and coma have been reported. Effects on the central nervous
system may include euphoria, hyperexcitability and alertness, rambling
speech, deliria, uncontrollability, transcendental mood, distractability,
depersonalization and impairment of judgement. A temporary psychotic
state with sensory illusions, distortions or visual hallucinations
consisting of shimmering intensification of color and texture,
brightly colored lights, geometric designs, animals and occasionally
human images may occur. Hearing or tasting colors and seeing sounds have been reported. Rarely, anxiety, fearful auditory, visual and tactile
hallucinations, panic states and paranoid delusions, suspiciousness,
emotional lability, intense depression, loss of control, suicidal
ideation and self destructive or aggressive acts may occur. Deaths
have resulted from hallucinatory effects leading to accidental
death. Additional effects due to lysergic acid diethylamide may include
salivation, lacrimation, hyperpyrexia, hypertension, piloerection, spastic
paresis, hyperacusis, suggestibility, prolonged psychosis, rarely,
hyperglycemia and internal carotid arteriospasm with resultant cerebral
anoxia and seizures. Inflammatory fibrosis has been reported. Studies
indicate that death in animals is due to respiratory failure or
hyperthermia. In the human adult, lysergic acid diethylamide has
been associated with breaks and other structural abnormalities of
chromosomes. A single study of pregnancies occurring after medically
administered doses did not show an increase in the rate of spontaneous
abortions, premature births, or congenital defects over the norm.
However, birth of abnormal babies has followed consumption of illicit
lsd by the mother in early pregnancy.
chronic exposure- repeated exposure may cause effects as detailed in acute ingestion. Flashbacks with hallucinations and distortion of
perception of time, space and self image may occur weeks or months
after the last dose. Tolerence and psychologic dependence may occur.
Fetal loss has been produced in rats following oral administration
of 20 micrograms of lysergic acid diethylamide between the first and
fourth day of gestation. No specific congenital defects were reported.
First aid- treat symptomatically and supportively. Get medical attention
immediately. If vomiting occurs, keep head lower than hips to prevent
aspiration.
antidote:
no specific antidote. Treat symptomatically and supportively.
------------------------------------------------------------------------------
reactivity:
stable under normal temperatures and pressures.
Incompatibilities:
Lysergic acid diethylamide:
No data available.
Decomposition:
Thermal decomposition products may include toxic oxides of carbon and
nitrogen.
Polymerization:
Hazardous polymerization has not been reported to occur under normal
temperatures and pressures.
------------------------------------------------------------------------------
|