Maybe by "today" he meant this era? *nudge*nudge* Right parkus? ;)

well thanks, I guess...

I was just wondering about some theoretical chemistry, searched google and totse to make sure it wasn't already covered, then made it very clear that I wasn't looking for some crank lab style BS.

I thought possibly someone would have an answer, and if not possibly it would lead to some interesting conversation.

but instead I get a bunch of crap answers that nobody put any thought into. I feel like idiots who ask "how does I maeks the meth" get more legit answers than does my never before addressed concept

and as far as useful, I meant more powerful opiate/opiod

bravo.

well thanks, I guess...

I was just wondering about some theoretical chemistry, searched google and totse to make sure it wasn't already covered, then made it very clear that I wasn't looking for some crank lab style BS.

I thought possibly someone would have an answer, and if not possibly it would lead to some interesting conversation.

but instead I get a bunch of crap answers that nobody put any thought into. I feel like idiots who ask "how does I maeks the meth" get more legit answers than does my never before addressed concept

and as far as useful, I meant more powerful opiate/opiod

bravo.Don't you think if it was possible it would have been covered somewhere? Maybe that's why you've never seen the question asked before.

bravo.

Thanks :) Your welcome, if did a bit of research before maybe someone would have bothered to help you ;):(

How about O-demethylation to give the phenol, which is a metabolite (http://en.wikipedia.org/wiki/O-Desmethyltramadol) of tramadol with 200x stronger affinity for the mu- receptor and a longer half-life. Dunno about how stable it is though...

Otherwise, as a building block to access morphine derivatives, while I'm sure it could be done, there are far easier ways to do it.

I haven't seen to many O-demethylations that don't involve N-demthylations as well.

I haven't seen to many O-demethylations that don't involve N-demthylations as well.

but it does look like the enzymatic process does the trick...now to get your hands on some of those enzymes.

but it does look like the enzymatic process does the trick...now to get your hands on some of those enzymes.

Naturally I excluded those.

This (http://www.evilshare.com/a59cfa54-c7f3-102b-b7cf-000b6aa2a5f8) may shed some light...

I always found tramadol more potent than codeine and vicodin.

Rage all you want, I don't know if tramadol metabolizes through the same enzyme, but even at the lower doses of tram. I still nod.

I would be jealous too, it's ok.

http://en.wikipedia.org/wiki/O-Desmethyltramadol

I remember i did the dumbest thing ever once, i had about 7g of tramadol in 50mg capsules and i was parachuting about 200mg every 4 hours or so to keep the buzz going and it was nice; comparable to about 20mg of oxy at the time. I decided to just dump all the capsules out into one big pile and just shovel a little into a cigarette paper every time i wanted to dose.... needless to say once i'd dumped it all out i'd realized that i had no way of measuring my dose each time and ended up doing about 4g in 5 hours... i was high for thee fucking days no lie, it was awesome.

wouldnt finding a chemical for a use, involve a use for a chemical?

I remember i did the dumbest thing ever once, i had about 7g of tramadol in 50mg capsules and i was parachuting about 200mg every 4 hours or so to keep the buzz going and it was nice; comparable to about 20mg of oxy at the time. I decided to just dump all the capsules out into one big pile and just shovel a little into a cigarette paper every time i wanted to dose.... needless to say once i'd dumped it all out i'd realized that i had no way of measuring my dose each time and ended up doing about 4g in 5 hours... i was high for thee fucking days no lie, it was awesome.

I was high for about 5 days from doing something similar, but I never exceeded 300mg per 6 hours. I read somewhere that recreationally 300mg was the best you could get, after which it stops metabolising properly and starts to fuck you up, like seizures and such.

I don't see how having the 4g would have done anything to boost your high if that's true, except for possibly inducing a seizure.

wouldnt finding a chemical for a use, involve a use for a chemical?

The point is that you should start with a chemical and try to find out what to do with it, but rather decide what to do and figure out what chemicals to use.

You have go to be shitting me...your a new arrival secretly!

I don't come in here, and rarely BLTC, which is where (I've gathered) stupid noob spends his time.

I was high for about 5 days from doing something similar, but I never exceeded 300mg per 6 hours. I read somewhere that recreationally 300mg was the best you could get, after which it stops metabolising properly and starts to fuck you up, like seizures and such.

I don't see how having the 4g would have done anything to boost your high if that's true, except for possibly inducing a seizure.

I already knew about the seizure risk, but the chances seemed pretty low. And if it stops metabolizing after 300mg that doesn't explain why i was nodding for days on end.

I already knew about the seizure risk, but the chances seemed pretty low. And if it stops metabolizing after 300mg that doesn't explain why i was nodding for days on end.

I used to injest upto 1000mg to start my day, never had a seizure.

However, my ex gf used to take upto 400-500mg, and seizured after 80mg one night.

I already knew about the seizure risk, but the chances seemed pretty low. And if it stops metabolizing after 300mg that doesn't explain why i was nodding for days on end.

well... presumably, if there is a maximum saturation in terms of metabolism, as your body dropped back below this level there were more supplies in your blood stream which could bind to the receptors / enzymes in question...

I already knew about the seizure risk, but the chances seemed pretty low. And if it stops metabolizing after 300mg that doesn't explain why i was nodding for days on end.

Hey, I may very well be wrong about the metabolism, but still it's probbably not worth it for running the risk of a seizure, in my opinion.

Hey, I may very well be wrong about the metabolism, but still it's probbably not worth it for running the risk of a seizure, in my opinion.

*lives to tell the tale seizure free*

I haven't seen to many O-demethylations that don't involve N-demthylations as well.

...but I haven't seen to many primary amines which couldn't be selectively remethylated somehow. ;)

...but I haven't seen to many primary amines which couldn't be selectively remethylated somehow. ;)

I rather like the selective O-demethylation in that paper - not sure I've seen this method before...

Presumably the use of isotopic methyl groups is purely incidental to the selectivity, as they get exclusive O-demethlyation either way round. Lovely !

...but I haven't seen to many primary amines which couldn't be selectively remethylated somehow. ;)

You've always gotta be right, don't you?

You've always gotta be right, don't you?

but he was agreeing with you...!

but he was agreeing with you...!

I know; I was criticizing my own lack of thought.

I know; I was criticizing my own lack of thought.

When you refuse to take "no" for an answer, all things are possible.

...including the "impossible arbitrary challenge." Like turning roses into meth. Or LSD from sawdust.

Or an advanced multidisciplinary civilization from your own poop in a supermax cell. Which is really the leading standard of applied science, in my opinion.

'cause when you've got jack, 'n shit - you don't really need Jack. 'n can mine him for raw materials if he pisses you off.

Total independence. Autonomous technoprimitivism. It's a way of life. :D

LSD from sawdust.

*waits*

Are you thinking of sawdust -->benzene and so on?

*waits*

Are you thinking of sawdust -->benzene and so on?

No, I think he's talking about sawdust to lysergic acid directly, via the Plinkle-Oschlen-Combo-Dingo-Dongo reaction, followed by a HATU coupling ;)


sorry, couldn't resist...

the Plinkle-Oschlen-Combo-Dingo-Dongo reaction

Would you like fries with that, sir?

Would you like fries with that, sir?

Nah, just a burger (http://tinyurl.com/ywvsse) please, you CuNT (http://tinyurl.com/ytltlz)... ;)

Nah, just a burger (http://tinyurl.com/ywvsse) please, you CuNT (http://tinyurl.com/ytltlz)... ;)

oh i c wut u did thar

Nah, just a burger (http://tinyurl.com/ywvsse) please, you CuNT (http://tinyurl.com/ytltlz)... ;)

Fucking macromolecules--making me look childish for playing with small-scale organic reactions.