What about having a different salt? (sulphate)

You end up with a base at the end anyway, so the actual salt form is almost a moot point. The only difference it makes is adjusting weight of PSE added, since obviously it is only the PSE base molecule reacting. You pretty much have to account for whatever extra ion is present when calculating your stoich.



Two samples, each weighing the exact same, one is base, and one is a salt, both are ran through, the base will have a higher yield.


If you were to calculate it as the HCl salt weight, and it was actually a base upon reaction, you would end up with unreduced PSE. Ya dig?

You end up with a base at the end anyway, so the actual salt form is almost a moot point. The only difference it makes is adjusting weight of PSE added, since obviously it is only the PSE base molecule reacting. You pretty much have to account for whatever extra ion is present when calculating your stoich.



Two samples, each weighing the exact same, one is base, and one is a salt, both are ran through, the base will have a higher yield.


If you were to calculate it as the HCl salt weight, and it was actually a base upon reaction, you would end up with unreduced PSE. Ya dig?

ah dig ;)

Thanks for that, i read about it over at WD but never bother too look into it:(

Ephedrine (http://en.wikipedia.org/wiki/Ephedrine) and pseudophedrine (http://en.wikipedia.org/wiki/Pseudophedrine) have the same chirality at the centre retained in methamphetamine (http://en.wikipedia.org/wiki/Meth).

As the aim in this case would be to remove the hydroxyl group, thus rendering the chirality of that centre in the starting material irrelevant, it doesn't matter whether one were to start with pseudo or ephedrine - assuming the method in question does not alter the stereochemistry at the other chiral centre.

thx

Actually, tis true that the 'l Pseudo ((-) Pseudo) won't reduce to meth and retains its effective decongestant properties (whilst having fewer side effects, too, apparently) however, the problem of it not reducing and one not wanting to buy it in error is kind of a moot point.....as Pfizer/Warner-Lambert who hold the patent, I believe, have never sought approval for sale and as such it is NOT available to the public.

So, one cannot 'buy the incorrect' pse as it is an impossibility that one would be served l-pse.

However, ephedrine is different both isomers are available but both reduce to meth BUT one makes classic d-meth and the other l-meth. d-meth is strong and long-lasting whilst l-meth is weaker. There is also, apparently, d/l meth which some say is the better than just pure d-meth due to it's more 'balanced' body and fine nose. A vintage 48 cannot be beaten, apparently.

NB In the UK the sale of ephedrine is illegal and pse has undergone the effects of Paranoid MP's - (dickheads n overweight Booted dykes.....Harriet Harmon (or whatever) - 2nd in line and a total fucking biyatch in the extreme - Extreme Feminist, apparently) and pse has had it's status changed so whereas you could go and buy 3 packs of 24, now you can only buy 12 and they can only be of 60mg (120mgs is available but the pack size will be less as there is a maximum amount of active allowed)


That's it

Actually, tis true that the [l-pseuoephedrine] won't reduce to meth and retains its effective decongestant properties
So, one cannot 'buy the incorrect' pse as it is an impossibility that one would be served l-pse.






Actually, this is not true - All four diastereosisomers will reduce to either d- or l- methamphetamine...

i.e. the optical isomers of pseudoephedrine will reduce to exactly the same compounds as the corresponding isomers of ephedrine.

The point about the lack of availability is valid however, so this becomes a non-issue.