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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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 #1 
Old 2008-08-04, 00:51
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NJ
Default serotonin-dopamine reuptake inhibitor

..........
 #2 
Old 2008-08-04, 01:29
spl1ff spl1ff is offline
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Default Re: serotonin-dopamine reuptake inhibitor

correct me if i'm wrong, but isn't meth an sdri?
 #3 
Old 2008-08-04, 01:39
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NJ
Default Re: serotonin-dopamine reuptake inhibitor

Dextro-methamphetamine hydrochloride is a potent central nervous system stimulant that reverses the direction of flow in the norepinephrine, dopamine and serotonin transporters, sending these neurotransmitters from the vesicle into the synapse instead of storing them in the vesicle for future use. The compound also inhibits the reuptake of the transmitters into the pre-synaptic (sending) neuron, causing them to remain in the synaptic cleft longer. The resulting increased levels of dopamine and norepinephrine in these synapses affect neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions.

^^from wiki

i think that means its an sndri, like tesofensine and bresofensine. there are sndris, snris, ndris, ssris, dris, nris, yet no sdris.
 #4 
Old 2008-08-04, 03:29
Aerogone Aerogone is offline
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Default Re: serotonin-dopamine reuptake inhibitor

Sure, dopamine re uptake inhibition is done by: Coke & Ritalin Mad

Meth on the other hand reverses the re uptake of dopamine, making it that much more addictive.... the amount of dopamine that you pump back out is INSANE....
 #5 
Old 2008-08-04, 03:38
Aerogone Aerogone is offline
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Default Re: serotonin-dopamine reuptake inhibitor

And as for stopping the breakdown of dopamine... WTF do you think MAOI's do... Hu?

Interestingly I have recently recommended, and shipped my mother a few sets of an MAO-B inhibitor. Works wonders for the aging/empty-nest/menopausal depression.

aerogone check yo email

Will do!
 
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