dont fucking question joepedo, he fucking knows his shit.

Blow me, after your done blowing Joepedo, make sure to wash with ethanol first though bitch. I smell pretentiousness and mindless followers.

dont fucking question joepedo, he fucking knows his shit.

You're a fucking faggot.

dont fucking question joepedo, he fucking knows his shit.

So? He did exaggerate a few things, and to be fair I think the OP is just drug ignorant rather than a troll.

If one can question God, then one can sure as fuck question JoePedo.

el oh el, good point, dude man

Sounds like MASSIVE and SEVERE exaggeration. You are so full of shit.

RLY?

"Permanent" damage with drugs tends to be bullshit... it seems to create a lasting degree tolerance to euphoria

You're contradicting yourself a tad.

"Permanent" damage with drugs tends to be bullshit also because the brain heals slowly with minor shit (as opposed to stroke/seizure damage)

Seizures ain't shit.

http://www.google.com/search?hl=en&q=MDMA+dopamine+peroxide

http://en.wikipedia.org/wiki/Raphe_nuclei

...that's an entire organ - and at least two entire neurotransmitter systems... gone. 'n popping your dopamine release agonist on the comedown pretty much ensures that "gone" is a totalitarian assertion, rather than just picking off a handful of neurons here and there.

Incidentally, the Raphe nucleus, in addition to being the only serotonin neurotransmission in the brain, is also the only endorphin neurotransmission in the brain... if you thought withdrawls were un-fun... try having an empty hole where your brain tissue used to be. Yes, literally.

High-efficiency axon-destroying neurotoxins - whether it's MPTP, botulotoxin, or time-staggering the already obscenely destructive amp/mdma combo to maximize neuron death - are bad things. Period. I hate to say it, but there's seriously no way around that fact.

Feel like disagreeing? "Quit the DARE bullshit?" Great - DO IT, FAGGOT. Counteract the crash of a half-gram of molly with a quarter gram of dex-amp, and come back and tell us how fun your life is, weekend after weekend. Let us know how it goes. Bonus points for an MRI at the six-month mark. I wanna fap to the cerebrospinal fluid sloshing around in the empty fuckin' hole, 'cause the DEA release was a bullshit fMRI activity scan showing that MDMA users were calmer than nonusers - but massive cell death leads to necrosis and nutrient reabsorbtion.

So, go ahead. Do it, faggot. Megadoses timing the initial dopamine rush of the amphetamine to the peak serotonin depletion of the MDMA. I wanna see you perform some precisely-engineered ablative self-neurosurgery.

...or at least post dox if you're intending to challenge the peroxidization hypotheosis... which, thankfully, is essentially a non-issue in nonabusive MDMA use which doesn't pop VMAT-2 inverters in the middle of a fuckin' crash.

You, umm... got dox on your challenge of the current paradigm of molecular interaction? Curious...

So? He did exaggerate a few things...

Not as much as you might think... ;)

Read it again. I wrote coadministration off as a "bad idea" (which it is, for the molecular reasons linked in the google search)...

...but I saved the actual "instantly dangerous" advisory for timing the initial dopamine rush to coincide perfectly with the peak depletion of the crash. Read 'em as two seperate things...

...then ya wanna disagree, fine... but read as written. ;)

Whilst you're here, how bad is taking MDMA 2 days in a row for your brain?

RLY?



You're contradicting yourself a tad.



Seizures ain't shit.

http://www.google.com/search?hl=en&q=MDMA+dopamine+peroxide

http://en.wikipedia.org/wiki/Raphe_nuclei

...that's an entire organ - and at least two entire neurotransmitter systems... gone. 'n popping your dopamine release agonist on the comedown pretty much ensures that "gone" is a totalitarian assertion, rather than just picking off a handful of neurons here and there.

Incidentally, the Raphe nucleus, in addition to being the only serotonin neurotransmission in the brain, is also the only endorphin neurotransmission in the brain... if you thought withdrawls were un-fun... try having an empty hole where your brain tissue used to be. Yes, literally.

High-efficiency axon-destroying neurotoxins - whether it's MPTP, botulotoxin, or time-staggering the already obscenely destructive amp/mdma combo to maximize neuron death - are bad things. Period. I hate to say it, but there's seriously no way around that fact.

Feel like disagreeing? "Quit the DARE bullshit?" Great - DO IT, FAGGOT. Counteract the crash of a half-gram of molly with a quarter gram of dex-amp, and come back and tell us how fun your life is, weekend after weekend. Let us know how it goes. Bonus points for an MRI at the six-month mark. I wanna fap to the cerebrospinal fluid sloshing around in the empty fuckin' hole, 'cause the DEA release was a bullshit fMRI activity scan showing that MDMA users were calmer than nonusers - but massive cell death leads to necrosis and nutrient reabsorbtion.

So, go ahead. Do it, faggot. Megadoses timing the initial dopamine rush of the amphetamine to the peak serotonin depletion of the MDMA. I wanna see you perform some precisely-engineered ablative self-neurosurgery.

...or at least post dox if you're intending to challenge the peroxidization hypotheosis... which, thankfully, is essentially a non-issue in nonabusive MDMA use which doesn't pop VMAT-2 inverters in the middle of a fuckin' crash.

You, umm... got dox on your challenge of the current paradigm of molecular interaction? Curious...

Your half-assed google/wikipedia posts aren't worth shit. As I have said, you pretentious jizz guzzler, certain_people have done both repeatedly for days with high doses of each WITHOUT ANY OF YOUR SCARE TACTIC BULLSHIT HAPPENING.

The tolerance was to drug euphoria, yes that is probably is a minor brain fuck. But what about anxiety/depression, cognitive impairment etc? If the laughable bullshit you spewed was true, people would turn into vegatables after a repeated high dose combo binge. Stop worshipping Richard Nickson and pull your head out of your ass.

Yeah, I know dopamine is toxic to seratonin cells when the seratonin reuptake channels are gaped like your asshole from mdma and it gets inside but you are being rediculous. I think the giant necrotic hole might be in your brain from your mom huffing to much raid when she was pregnant.

You think the insufflation of them both mixed together and finely pulversized at high doses would cause said occurance to happen well enough ;)

Assuming it's clean and this isn't in a pattern of longterm heavy abuse? Not too terribly. Depends a bit on what you've eaten since then, your dose at both times, 'n you probably aren't going to have as much fun on day 2 - but the only way to get a negative physiological effect from MDMA (aside from eating ounces at once) is to run dry on serotonin in the presence of dopamine...

Since you probably didn't burn all your serotonin totally on day one, 'n since you've probably eaten inbetween, chances are that unless you take some sort of ungodly fucking dose (or are already hurting from several years of rolling three times a week), you might lose a few neurons at the higher end of dose (say, >160mg) , but probably not enough to notice any effect - most of the problems you can actually percieve will be the short-term depression coming from just ordinary low serotonin, which should go away in a couple days.

...don't do it every day, but I'd guess that if you just did it every year with more moderate use for the rest of the year, you'd be able to avoid negative side effects with a decent margin of saftey on top of it.

'n if you actually use harm-reduction such as tryptophan/vit c/ala/ssris on the comedown on top of that... virgin brain tissue, baby, from harder use than that.

The current harm reduction won't cover enzyme downregulation, though. ;) It'll preserve your brain, but won't stop prolonged-aqquisition mild, temporary depression. No biggie.

Assuming it's clean and this isn't in a pattern of longterm heavy abuse? Not too terribly. Depends a bit on what you've eaten since then, your dose at both times, 'n you probably aren't going to have as much fun on day 2 - but the only way to get a negative physiological effect from MDMA (aside from eating ounces at once) is to run dry on serotonin in the presence of dopamine...

They were pretty strong pills, some sort of MDxx compound, who knows what else, and had nothing to eat from friday lunch until sunday lunch, but I was just asking because I kept going light headed when I stood up and this really weird like... feeling behind my eyes for a few days afterwards, almost like a buzzing sensation if you get me, it's hard to describe, and I've never really heard that described in the usual symptoms of a comedown.

Your half-assed google/wikipedia posts aren't worth shit.

More refs than you've got. /fin.

Yeah, I know dopamine is toxic to seratonin cells when the seratonin reuptake channels are gaped like your asshole from mdma and it gets inside but you are being rediculous. I think the giant necrotic hole might be in your brain from your mom huffing to much raid when she was pregnant.

~shrug~ You heard me. Log off the net 'n do it. .5g/.25g, exact substances outlined, exact timeline outlined. Six month challenge.

Quit talkin', start walkin' it. Do it faggot.

I was just asking because I kept going light headed when I stood up...

That's what happens when you run low... (http://hyper.ahajournals.org/cgi/content/abstract/5/5/676)

Generally speaking, if you aren't experiencing signifigantly disordered anxiety a couple months afterward, you haven't broken anything serotonergic yet. ;) In fact, anything that goes away in a few days isn't related to neuron death...

I'd probably take a break if I found the symptoms you described, but it's not quite worrisome yet, just a gentle warning from the drug. Personally, I'm surprised the temperature effects didn't manifest before the bp effects, but hey, that's what happened...

It should work out fine... just don't do that too often. ;)

RLY?



You're contradicting yourself a tad.



Seizures ain't shit.

http://www.google.com/search?hl=en&q=MDMA+dopamine+peroxide

http://en.wikipedia.org/wiki/Raphe_nuclei

...that's an entire organ - and at least two entire neurotransmitter systems... gone. 'n popping your dopamine release agonist on the comedown pretty much ensures that "gone" is a totalitarian assertion, rather than just picking off a handful of neurons here and there.

Incidentally, the Raphe nucleus, in addition to being the only serotonin neurotransmission in the brain, is also the only endorphin neurotransmission in the brain... if you thought withdrawls were un-fun... try having an empty hole where your brain tissue used to be. Yes, literally.

High-efficiency axon-destroying neurotoxins - whether it's MPTP, botulotoxin, or time-staggering the already obscenely destructive amp/mdma combo to maximize neuron death - are bad things. Period. I hate to say it, but there's seriously no way around that fact.

Feel like disagreeing? "Quit the DARE bullshit?" Great - DO IT, FAGGOT. Counteract the crash of a half-gram of molly with a quarter gram of dex-amp, and come back and tell us how fun your life is, weekend after weekend. Let us know how it goes. Bonus points for an MRI at the six-month mark. I wanna fap to the cerebrospinal fluid sloshing around in the empty fuckin' hole, 'cause the DEA release was a bullshit fMRI activity scan showing that MDMA users were calmer than nonusers - but massive cell death leads to necrosis and nutrient reabsorbtion.

So, go ahead. Do it, faggot. Megadoses timing the initial dopamine rush of the amphetamine to the peak serotonin depletion of the MDMA. I wanna see you perform some precisely-engineered ablative self-neurosurgery.

...or at least post dox if you're intending to challenge the peroxidization hypotheosis... which, thankfully, is essentially a non-issue in nonabusive MDMA use which doesn't pop VMAT-2 inverters in the middle of a fuckin' crash.

You, umm... got dox on your challenge of the current paradigm of molecular interaction? Curious...

ummmm.....oops

I read like 3 words of this and saw it involved some child going to a concert

I'm surprised I even typed this though I type in 97% of threads I read

More refs than you've got. /fin.



~shrug~ You heard me. Log off the net 'n do it. .5g/.25g, exact substances outlined, exact timeline outlined. Six month challenge.

Quit talkin', start walkin' it. Do it faggot.

What have you done? I've implied it was already done without the bullshit you described. Massive Adderal/bomb E insufflated repeatedly.

Keep talking your far-fetched theories asshole. Why don't you try you cocksucking pussy? In practise, those super neuron kill fantasies of your just don't hold true.

dont mix hard stims like that

What have you done? I've implied it was already done without the bullshit you described. Massive Adderal/bomb E insufflated repeatedly.

Keep talking your far-fetched theories asshole. Why don't you try you cocksucking pussy? In practise, those super neuron kill fantasies of your just don't hold true.
Could you please retype that into something understandable? It's hard to take you seriously when you can't even spell the word practice correctly. And it's funny to see you try and refute joepedo while making such retarded errors.

Why don't you try you cocksucking pussy?

Yeah, umm... if you'd been reading the thread, you would've noticed that my putting my action where my talk is would involve not timing peak dopaminergic flush to interrupt the crash.

For that matter, if you've read, you would've also noticed that everything you "implied," stupid as it is, really doesn't fucking pertain to the proposal under discussion in any but the most obscenely remote sense. Sort of kills your whole tangent.

Personally, I'd love a list of drugs and environmental toxins you have been exposed to on a regular basis. We can be sure of one thing - the glaring and extreme neurological deficiencies you amply display in this thread could not have come from MDMA use in even the slightest capacity.

Kinda douchie in it's presentaion, but good information none the less.


'n if you actually use harm-reduction such as tryptophan/vit c/ala/ssris on the comedown on top of that... virgin brain tissue, baby, from harder use than that.



SSRI's? I got perscribed Citalopram last week but I didn't want to start it until after the concert. I was worried about mixing the two and possibly fucking up my liver. So if I start the SSRI the day after the concert, like while im in my E hangover, it'll reduce possible brain damage? I was going to use 5htp. Are SSRI's and 5htp safe to use together?

why the fuck would you ruin the x? and why the fuck would you wanna feel like a robotic zombie by taking adderall? i say fuck adderall.

You're a fucking faggot.

headbutt a bullet.

So if I start the SSRI the day after the concert, like while im in my E hangover, it'll reduce possible brain damage?

Ideally, right at comedown...

Neuron death forms when the serotonin reuptake transporter starts transporting dopamine instead, usually as a result of serotonin depletion. Serotonin reuptake inhibitors, such as the SSRIs (or MDMA itself, actually), prevent... well, anything... from being drawn back up into the cell, which... well, prevents dopamine from being drawn into serotonergic terminals.

So, yeah. It's helpful. As for SSRIs + 5HTP... it's [u]usually[/i] safe. Dosage is meaningful to the saftey margin, but there's a degree of tryptophan in food already (thankfully)... and if you're just starting, you're on the low end of the dosage spectrum. Citalopram is a bit more of a concern than most due to its rapid uptake, but... if your doctor didn't give you a list of restricted high-tryptophan foods, it should be alright.

Tryptophan and 5HTP prevent peroxidization by making serotonin avaliable to the reuptake transporter, btw...