I have been on a bit of an adderall binge. Not a hardcore binge - I still eat (occasionally) although not nearly as much as I should. I have done a lot of research and I was hoping some knowledgeable people here might be able to give me some information on a few substances when they are combined or pre/post loaded with adderall. (Sorry for another adderall thread BLTC, but I havn't found any of these answers in any other thread, and this is a little different than "how do I shoot/snort my XR beads? lulz).

L-Phenylalanine - Should I mainly post/pre load with this? How efficient will it be at raising my dopamine levels? Does it need to build up in the body, like 5-HTP when used as an anti-depressant, or will one dose make a difference? Any risk factors involved here? How does tyrosine differ, and is one better than the other?

JP's L-Phen combo - In the last thread about JP's combo, he said


...but if you really want an answer to "can my body even do anything with this" - pop it during a meth crash. You'll get an answer, for your body, rather quickly.

- jp (Referring to the combo, not just L-Phen I assume)
Does he mean this will work exceptionally well on a (meth)amphetamine comedown ? Any dosages you would change? Should you dose this directly on the comedown or the next morning or what, cause I assume it will make it a little harder to sleep. Will this just alleviate the comedown effects, or could it possibly make you feel euphoric? Hah! Feeling good on a speed comedown, what an oxymorphon...oxymoron, rather. ;-)

L-Theanine - It seems theanine would be a great thing to pre/post load with, or even possibly take with it. It promotes relaxation by producing alpha waves in the brain. It also increases serotonin, dopamine, and GABA and has micromolar affinities for NMDA receptors, which is related to amphetamine tolerance, I believe. It also helps maintain a healthy immune system and convert fat to muscle. Sounds like an excellent substance, which could be beneficial for many things, ya?

Propranolol- Propranolol is a beta blocker that is mostly prescribed for heart problems such as hypertension, angina pectoris, tachyarrhythmias, myocardial infarction etc. It is also used to help anxiety, or the physical side effects caused by anxiety, mainly tremors. I seem to get tremors badly the day after a speed binge. It seems this could definately help a speeding heart or abnormal heart beat etc... Anything dangerous about this?

Huperzine A - Huperzine is generally praised by many as a 'smart drug'. It increases levels of dopamine and norepinephrine, while also being an NMDA receptor antagonist, which is linked to reducing amphetamine tolerance, I believe. Increased levels of dopamine/NE=more spun, ya!?

Requip- Dopamine agonist. Activates dopamine receptors, mimicking the effect of dopamine. Could this possibly have any benefits when combined with adderall?

Basically I am looking for any personal experiences people have had with this or the basic pharmacology behind mixing these substances (mainly the L-phen combo) with amphetamine (from educated people, please). Also, any information about good things to mix with amphetamine to potentiate it or alleviate the negative effects would be appreciated. (I already know about anti-acids for better absorption and DXM for lower tolerance)

God it's late and I am strung out...sorry if the post is rough around the edges, as I am a little rough around the edges at the moment.

Thanks, bitches.

Edit: If anyone knows how I could get ahold of Joe Pedo, please let me know, that would be awsome.

Take the phenylalanine combo the day before you start on the speed and then every day throughout your binge. Take magnesium at night too when you start to feel burnt-out.

...and shitloads of vitamin C or other strong antioxidants; the peroxide formed in your brain won't go away by itself ('cept maybe by attacking your pleasure chemical receptors).

Edit: If anyone knows how I could get ahold of Joe Pedo, please let me know, that would be awsome.

Step 1, post, step 2, I post some useless tripe to lodge it in my CP and come back to it in a day or two...

...if you really need to get my attention, LT has a bullshit thread which I'll probably eventually check, as long as the posting rate thereto doesn't soar too much above the current rate...

Does he mean this will work exceptionally well on a (meth)amphetamine comedown ?

Well, it sure the fuck becomes more immediately noticeable at that time...

...aside from any sweating, anxiety, or other crap, a meth crash tends to consist of either rage, or extreme depression.

The former is a 100% correlative diagnostic for having shit for dopamine. The latter tends to imply having low serotonin... along with shit for dopamine.

'n if you're raging, it only takes a very, very, very few milligrams to take that all away in an instant. The difference between "adequate" neurotransmission and "excessively ample" neurotransmission may be somewhat large, but the difference between "no" and "low" dopamine is infitesimally minute. More of a "magic trick" than anything else, really.

'n yes, I've occasionally been known to hand 5mg phenylalanine pills to people having a bad day. A drop of mint oil and a 'toids carrying tin, and they don't even know - the mystic angel in their midst is just really, really soothing to talk to.

~shrug~ Anything I can do to help out, y'know...

L-Phenylalanine - Should I mainly post/pre load with this?

Yes.

Does it need to build up in the body, like 5-HTP when used as an anti-depressant, or will one dose make a difference?

Both. ;)

Any risk factors involved here?

Tyramine pressor response in conjunction with MAOIs. Shouldn't be any problem that wouldn't preclude amphetamine use anyway...

How does tyrosine differ, and is one better than the other?

Tyrosine cannot decarboxylate to phenethylamine, which is the neurotransmitter analog of amphetamine (alpha-methyl-phenethylamine, to give amp's full chemical name).

Since you're using... amphetamine... as the amphetamine, tyrosine would probably be more predictable and reproducible as a support for amphetamine use.

Any dosages you would change?

If using amphetamines, I would increase the magnesium.

Should you dose this directly on the comedown or the next morning or what

Considering that it should function as a "total abort" of the comedown, I for one wouldn't want to wait.

The choice, of course, is yours, and if you've been loading throughout the binge, there's a good chance that you might not get a comedown.

I know it works for thujone rage. ;) 'n the lobelidine family of alkaloids...

L-Theanine - It seems theanine would be a great thing to pre/post load with, or even possibly take with it. It promotes relaxation by producing alpha waves in the brain. It also increases serotonin, dopamine, and GABA and has micromolar affinities for NMDA receptors, which is related to amphetamine tolerance, I believe. It also helps maintain a healthy immune system and convert fat to muscle. Sounds like an excellent substance, which could be beneficial for many things, ya?

Sounds interesting. I've never heard of it being coadministered. Let us know how that goes.

Propranolol- Propranolol is a beta blocker

Expect a decrease in stimulation from the coctail.

I seem to get tremors badly the day after a speed binge.

That's because you deplete yourself to the point of temporary parkinsons'. Check y'self, and practice proper harm reduction techniques.

Huperizine A... increases levels of dopamine and norepinephrine

...mostly through the methodology prior established, I presume..

Dopamine agonist. Activates dopamine receptors, mimicking the effect of dopamine. Could this possibly have any benefits when combined with adderall?

Lol... depends on your definition of "benefits." Expect sexual side effects.

the basic pharmacology behind mixing these substances (mainly the L-phen combo) with amphetamine (from educated people, please).

Think of it in terms of finance. Catecholamines are "money." Amps are a spending binge. l-phen/l-tyr is an enhanced income. The "crash" is the 'bill' vs. savings, and your spending rate is determined in part by exactly what it means to immediately spend everything you make along with a constant percentage of your savings.

Also, any information about good things to mix with amphetamine to potentiate it

Let's see... the l-phen/l-tyr itself should potentiate things somewhat, the caffiene part thereof should be a bitchin' potentiator (NE signals through cAMP, caffiene prevents that signal from being turned off)...

...other than that, the only potentiator is receptor reregulation, which is covered in Mg++...

...or, shutting off your GABA systems. That's... pretty hardcore. Y'might want to wait until you can STOP yourself from getting "parkinsons'" as a side effect from a binge before you even think about trying that one.

or alleviate the negative effects would be appreciated.

Mg++/DXM/Memantine/ketamine, maybe an SSRI... some sort of catecholamine precursor... moderation...

Thanks for the reply JP, it is much appreciated.

I have been using the cocktail, almost every time I come down, and a couple hours before I redose. I have noticed a definite decrease in negative effects that come with stimulant comedowns. I have also noticed it seems to make the high cleaner, more like a normal state of mind rather than a chemically induced tweek, but with the same positive effects you look for from adderall.

I have a few more questions for you (or anyone knowledgeable)...

St Johns Wort- I have read it could possibly be dangerous when mixed with amphetamines, and just generally a risky substance to mix with other drugs, so I have not yet tried it for overstimulation, although there have been many times i'm sure I could have used it. What are your thoughts on this?

Now, I know you mentioned Mg++, ketamine, dxm, and memantine as some NMDA antagonist's to help with neurotoxicity and tolerance. I use Mg++ daily(what would you suggest as a safe daily dosage? how often should I dose?). What about Amantadine? I have access to it. It is a NMDA antagonist, induces release of dopamine, and stimulates norepinephrine response. Any knowledge you could share about this? Edit: Here is the only info I have found on Amantadine being used for amphetamine tolerance -
"3) Amantadine, originally used in the treatment and prophylaxis of influenza infection and drug-induced Parkinsonism, also blocks NMDA receptors. Besides it is beneficial in traumatic head injury, dementia, multiple sclerosis,cocaine withdrawal and depression. Amantadine appears to act through several pharmacological mechanisms, none of which have been identified as the one chief mode of action. It is a dopaminergic, noradrenergic and serotonergic substance, blocks monoaminoxidase A and NMDA receptors, and seems to raise beta-endorphin/beta-lipotropin levels. I couldn't find what amount of the drug should be used to block NDMA. Cheaper than Acamprosate. No one has tested it yet, but I think it would be a good choice."

Thanks.