http://www.springerlink.com/content/n0mufmcm9efhjg44/?p=d67eb2821f3d4a519248b745e07965d3&pi=0


Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) can partially reverse long-term loss of striatal dopamine transporters induced by multiple doses of methamphetamine via an unknown mechanism. This study was designed to examine the modulating effects of three opioid ligands, DADLE, Leucine enkephalin (L-enk), and naloxone, on the long-lasting dopamine depletion produced by 4 cumulative doses of methamphetamine. Both DADLE (at a dose of 18 mg/kg) and L-enk (100 μg/kg × 2) effectively attenuated methamphetamine-induced dopamine depletion in the striatum while their protective effects were not blocked by coadministration of naloxone. In contrast, naloxone (10 mg/kg × 2) alone potentiated the long-lasting dopamine depletion produced by methamphetamine. Moreover, none of the treatments with DADLE (18 mg/kg), L-enk (100 μg/kg), or naloxone (10 mg/kg) alone affected body temperature. These results suggest that the opioid ligands may, directly or indirectly, modulate this methamphetamine-induced dopamine neurotoxicity in the nigrostriatal system via a temperature-independent mechanism.


The next time you smoke meth to your dome take some DADLE (http://cancerweb.ncl.ac.uk/cgi-bin/omd?enkephalin,+leucine-2-alanine) and your set haha.

http://www.springerlink.com/content/n0mufmcm9efhjg44/?p=d67eb2821f3d4a519248b745e07965d3&pi=0



The next time you smoke meth to your dome take some DADLE (http://cancerweb.ncl.ac.uk/cgi-bin/omd?enkephalin,+leucine-2-alanine) and your set haha.

Aren't you on probation?
Something about a cellphone?

The next time you smoke meth to your dome take some DADLE

The next time you make a stupid thread you can DADLE my dick you fag.

Ifiotw