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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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 #1 
Old 2008-04-15, 19:53
Regular
 
Upstate
Default Tolerance: Benzos

hypothetically:
a steady consumption of about 4-5mg of ativan (lorazepam) for the last 4-5 days.
Due to... tolerance feels 4 mg of ativan to a much lesser degree.

besides waiting - is there anything that can be done? Is there a quick way to lower tolerance?

- I know that seems silly, but just wondering if some totsian out there knew some special secret I was unaware of.
 #2 
Old 2008-04-15, 20:00
Regular
 
NJ
Default Re: Tolerance: Benzos

yeah bro all you have to do is press the button on your gooch that says "lower benzo tolerance"
 #3 
Old 2008-04-15, 21:09
xxdarksidexx xxdarksidexx is offline
Regular
 
Default Re: Tolerance: Benzos

Quote:
Originally Posted by kwerjack
yeah bro all you have to do is press the button on your gooch that says "lower benzo tolerance"


LOL FUCKING OWNED.!!! Wean the fuck off man there aint no magic cures.
 #4 
Old 2008-04-15, 22:34
Regular
 
OPS 2A building 688-6911(b)
Default Re: Tolerance: Benzos

Wean the fuck off man there aint no magic cures.

For real.

If you could lower your tolerance at will don't you think every addict would be doing this and it'd be really well known?
 #5 
Old 2008-04-16, 00:57
Time Out Sasquatch Time Out Sasquatch is offline
Regular
 
Default Re: Tolerance: Benzos

Quote:
Originally Posted by tylerdurdenzs
hypothetically:
a steady consumption of about 4-5mg of ativan (lorazepam) for the last 4-5 days.
Due to... tolerance feels 4 mg of ativan to a much lesser degree.

besides waiting - is there anything that can be done? Is there a quick way to lower tolerance?

- I know that seems silly, but just wondering if some totsian out there knew some special secret I was unaware of.


Drink grapefruit juice with it. Be careful though.
 #6 
Old 2008-04-16, 01:25
42Oinchrims 42Oinchrims is offline
Regular
 
Default Re: Tolerance: Benzos

Drink grapefruit juice with it. Be careful though.

that only works with diazepam
 #7 
Old 2008-04-16, 01:40
Time Out Sasquatch Time Out Sasquatch is offline
Regular
 
Default Re: Tolerance: Benzos

that only works with diazepam

Are you sure? Because I thought it applied to all benzo's, and I personally thought it affected the strength of Xanax and ativan. Actaully I'm alost positive that in my mom's little packet they attach to her Xanax script that it specifically mentions not to drink grapefruit juice.
 #8 
Old 2008-04-16, 01:43
Regular
 
NJ
Default Re: Tolerance: Benzos

that only works with diazepam

you just asking for a link from me?

http://en.wikipedia.org/wiki/CYP3A4#CYP3A4_ligands
http://en.wikipedia.org/wiki/Alprazolam#Food_and_drug_interactions
benzodiazepines are substrates of this enzyme, grapefruit juice is a "strong inhibitor"
 #9 
Old 2008-04-16, 01:51
Time Out Sasquatch Time Out Sasquatch is offline
Regular
 
Default Re: Tolerance: Benzos

All I know is, that when I was addicted to benzo's physically I could take up to 10 milligrams of xanax and go to work, but if I drank a bottle of grapefruit juice with 2-4 milligrams of xanax that i usually wouldn't remember shit after the last gulp. I'd also usually wake in the shower with the water being ice cold, yet set to hot.
 #10 
Old 2008-04-16, 02:05
42Oinchrims 42Oinchrims is offline
Regular
 
Default Re: Tolerance: Benzos

http://www.mayoclinicproceedings.com/inside.asp?AID=1616&UID=

http://www.med.or.jp/english/pdf/2001_03/136_141.pdf (do ctrl f diazepam)

According to these sites its only diazepam, midazolam, and triazolam(sp?). NOt clonazepam or xanax. I dunno maybe im wrong, ive always thought it was just valium. I never noticed any difference taking xanax and grapefruit juice.

Edit: actually heres the exact same argument. http://www.bluelight.ru/vb/showthread.php?t=139536

you guys are prolly right, if it works for you go for it, it really only worked with valium for me.
 
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