So what the fuck is up with IV'ing codeine/codeine derivitives? I know that codeine and hydrocodone can potentially cause anaphylaxis, but why not oxycodone too? I know so many people who have shot up oxycodone without any allergenic side effects, so I don't get it, why would it be any different? I'm not planning on banging codeine or hydrocodone but I don't really understand this.

you fucking idiot.

you fucking idiot.

if hes such an idiot why dont you answer his question, becuz you dont know the answer either you dumbass. But im gunna leave the floor open fo ryou to prove me wrong.

and to the poster, what about the histmaines and luekos?

you fucking idiot.

You don't get to call anyone else that. Besides, he did nothing to prove he was an idiot, unlike yourself.

First off let me just say I DO NOT know the answer to the OPs question, but my guess is that codeine has to be converted into morphine before you get any effects. Oxycodone is a different drug entirely and is not converted into morphine. Someone that knows chemistry probably understands this a lot better.

God IWD you seriously fuck up every single thread on bltc with random pointless shit just for the sake of it. You're turning this forum into a big fucking pile of shit.

that is because he is a bitch with mental complications that he feels he needs to insult people to convince his mind he has respect on this forum. just ignore the motherfucker. pay him no fucking attention, because thats what he wants. who gives a shit what he thinks anyway he obviously bases his assumptions on nothing. just a dumbass. and i hope he tries to insult me. i could give a fuck less.

IV codeine causes pulmonary oedema if I recall correctly.

The point about oxy is moot, comparing different opioids in their pharmacokinetics is like comparing different breeds of dog. They're still dogs, but they're nowhere near the same.

I like the backstreet boys

haha this guy just said he likes the backstreet boys! what a fag!

In this case it's like some dogs are instantly freindly while others tend to aim for the jugular.

Basically, codeine has to be converted into morphine otherwise it causes massive histamine release, the only place this conversion happens is in the liver, thanks to some enzymes that i couldn't be fucked remembering. :)

AFAIK, leukotrienes have nothing to do with it.

The "allergic" symptoms are all because of histamine, and it has nothing to do with actually being allergic*. Also, oxycodone can cause the same symptoms. All opioids can. There are some people who get itchy as fuck from oxy, and some who don't. Just like there are people who get itchy as fuck from hydrocodone and those who don't. It's all about the individual.

* True and false. It can obviously be a sign of an allergy, but the vast majority of "allergic" reactions to opioids are just innocuous release of histamine. In your body, histamine is stored in cells that, for some reason, can be "triggered" by certain amines to release their stores of histamine. Some opioids just happen to be more likely to cause that release. Here's a chart that shows the relative risk of histamine release by opioid:


Opioid Classification of Relative Histamine
Chemical Source Release
Buprenorphine Semi-synthetic No data
Codeine Natural High
Fentanyl Synthetic Low
Hydrocodone Semi-synthetic No data
Hydromorphone Semi-synthetic Low
Levorphanol* Semi-synthetic Low
Meperidine Synthetic High
Methadone Synthetic Low
Morphine Natural High
Nalbuphine Semi-synthetic No data
Oxycodone Semi-synthetic Low
Oxymorphone* Semi-synthetic Low
Propoxyphene* Synthetic No data

Taken from: http://depts.washington.edu/druginfo/DTT/2006_Vol35_Files/V35N4.pdf

Now, why do some of those drugs have a lower risk than others? Uh, well, iono :D

In this case it's like some dogs are instantly freindly while others tend to aim for the jugular.

Basically, codeine has to be converted into morphine otherwise it causes massive histamine release, the only place this conversion happens is in the liver, thanks to some enzymes that i couldn't be fucked remembering. :)

CYP2D6 at your service!



But suddenly, this thread makes sense. I couple of times I've had codeine and turned rather red and itchy. Now I understand! God bless BLTC for enlightening someone for a change!

you fucking idiot.

Little ironic...no?

CYP2D6:A4 at your service!



fixed.

You don't get to call anyone else that. Besides, he did nothing to prove he was an idiot, unlike yourself.

First off let me just say I DO NOT know the answer to the OPs question, but my guess is that codeine has to be converted into morphine before you get any effects. Oxycodone is a different drug entirely and is not converted into morphine. Someone that knows chemistry probably understands this a lot better.

Codiene is a prodrug of morphine. Which means it is converted to morphine. (which you understand) Oxycodone is also a prodrug. But it converts to oxymorphone. Hydrocodone converts to hydromorphone.

Codiene is a prodrug of morphine. Which means it is converted to morphine. (which you understand) Oxycodone is also a prodrug. But it converts to oxymorphone. Hydrocodone converts to hydromorphone.

I might be wrong, but I'm pretty sure that's not true.

I might be wrong, but I'm pretty sure that's not true.

No, I think he's right. At least I know he's right about Vicodin and Codeine. Hydrocodone gets converted into Hydromorphone in the liver, Codeine into morphine, and Oxycodone into oxymorphone.

No, I think he's right. At least I know he's right about Vicodin and Codeine. Hydrocodone gets converted into Hydromorphone in the liver, Codeine into morphine, and Oxycodone into oxymorphone.

I knew that about codeine and morphine, but I didn't know that about the others. I guess you learn something new each day.

I knew that about codeine and morphine, but I didn't know that about the others. I guess you learn something new each day.
I guess! I encourage you to go out and do your own research though.

Codeine is metabolized into norcodeine, morphine, and codeine-6-glucuronide. The norcodeine is further metabolized into normorphine. The morphine is further metabolized into even more normorphine, as well as morphine-3-glucuronide and morphine-6-glucuronide.

Hydrocodone is metabolized into norhydrocodone, hydromorphone, and hydrocodol. The norhydrocodone and hydromorphone are then metabolized to norhydromorphone. The hydromorphone is also metabolized into hydromorphol as is the hydrocodol.

Oxycodone follows the same metabolic pathways as hydrocodone, just replace the words "hydro" above with "oxy" and you've got your chart :p

There's a very good article in an issue of the journal Current Pharmacogenomics from a few years back entitled "Influence of CYP2D6 Genetics on Opioid Kinetics, Metabolism and Response", which is where I got this information. It explains the metabolism of codeine, dihydrocodeine, hydrocodone, oxycodone, and tramadol, including which enzymes do what, and is pretty easy to understand. I'll see if I can find an online copy of it.

Edit: Success! (http://www.bentham.org/cppm/Sample/cpg3-1/004AF.pdf)