Anyone see a problem with the 3500mg of Acetimophen that will be sitting in my ass with the 35mg of Hydrocodone?

I mean, if it's cool in my stomach, it should be cool in the bunghole, amirite?

Hmm the problem is.. ITS IN YOUR ASSHOLE.

Im not exactly sure, I wouldnt think it'd hurt but I just cant say for sure...

But this makes me wonder a very simple question, if you go through the trouble of plugging something why not take the extra 10 minute step of doing a Cold Water Extraction?

Also isn't Hydrocodone like Codeine not as good plugged b/c you want it to metabolize in the stumich to produce better metabolites?

Plugging brings with it a higher absorption of the contents involved..so I would assume it would be the same with APAP. It isn't only for the good stuff.

In short, no, it wouldn't be negligible. Your still at risk (possibly more-so) when shoving things up your ass.

I assumed as much, but I regularly handle 5,000mg+ APAP orally.

I'm starting to think it will just be a lot of material to have up there.

And is it even going to be more effective anally?

More efficient than just chewing it up? Yes. But there are better ways. Potentiation for instance.

Grapefruit juice and tonic water?

Got any good tips bud?

I assumed as much, but I regularly handle 5,000mg+ APAP orally.

your liver is going to hate you

The recommended maximum daily dose, for adults, is 4 grams. In recommended doses, paracetamol is safe for children and infants, as well as for adults.
...The metabolism of paracetamol is an excellent example of toxication, because the metabolite NAPQI is primarily responsible for toxicity rather than paracetamol itself.
Paracetamol overdose results in more calls to poison control centers in the US than overdose of any other pharmacological substance, accounting for more than 100,000 calls, as well as 56,000 emergency room visits, 2,600 hospitalizations, and 458 deaths due to acute liver failure per year.

i would CWE it then plug if i was you, or just eat the damn things, and i wouldnt eat more than 4 grams of apap at a time. just to be safe. buuut if you wanna kill your liver im not going to stop you.

I assumed as much, but I regularly handle 5,000mg+ APAP orally.

That's not good!

Also, you regularly handle it, but actually it's your liver that handles it..and this is going to catch up to you at one point or another.