I remember reading somewhere on Totse that proper LSD synthesis takes at least 3 years of college level Organic Chemistry knowledge and access to a full laboratory. If this is true, I was wondering what kind of people synth LSD. Obviously chemists but I was thinking more of looking at a specific demographic. i.e. old guys. And, please don't bitch, is it possible if you had the time to teach yourself the entire proper LSD synthesis and if you had money to pull it off?

young black men in the deep south.
no joke.

how would it be possible to teach yourself if it basically requires a college education (ie: others teaching you)

its not just the directions to synth it, it is all of the knowledge of chemistry, knowing EVERYTHING that could go wrong and how to counteract it.

Oh come on now - it's not THAT hard.

All you REALLY have to do is take some ergot fungus and put it in a blender. It blends (AKA Synthesises) the LSD-25 from the ergot.

I've done it many times, and I've only had TEN people need to go to the hospital to amputate their dying limbs!

Considering that I've done it to 30 people, that's good odds! Only 1/3 of the time is it ever messed up!

with enough research to understanding shulgins guide...

its just cooking, granted you wont really understand why and how the reactions are taking place but if you do it right you should end up with lsd... but so many things could go wrong, if you know what your doing you can hopefully fix whatever goes wrong...

even shulgin said "orbitals are for mathematicians - organic chemistry is for people who like to cook!"

but to understand whats happening it takes a good amount of organic chem knowlege... not necessarily a degree or college but a good understanding at least... i dont think joepedo ever went to college, but that man is a genius...

People like William Pickard (http://en.wikipedia.org/wiki/William_pickard).

you don't need a fucking degree in chem to synth acid. a piece of fucking paper doesn't synonymously give you the ability to synthesize anything you want. if you have basic chem knowledge, can read the synthesis and understand it, then you can synth it. it would help to have hands on experience with complex chemical reactions, but if you're careful, precise, and allow no deviation whatsoever then what could possibly go wrong?

the harder part is actualy getting the reagents, or the reagents to synth the reagents needed, or even the ones needed to create the ones needed to create lsd...

thats where chemists get caught, and thats where alot of your problem is. other than photosensitivity, needing to be synthed in an inert gas flooded enviroment, and has some pretty stringent temp specs on it.

how would it be possible to teach yourself if it basically requires a college education (ie: others teaching you)

you think stupid noob had all his chem knowledge forced down his throat? no, he learned it on his own accord because he has a goddamn passion for it. if you can maintain motivation and ambition then you can teach yourself just about anything.

I've done it many times, and I've only had TEN people need to go to the hospital to amputate their dying limbs!



You have never made LSD-25 and it is not as simple as you think.

People like William Pickard (http://en.wikipedia.org/wiki/William_pickard).


And :
http://en.wikipedia.org/wiki/Owsley_Stanley

http://en.wikipedia.org/wiki/Owsley_Stanley

This I found interesting because it says he dropped out when he became interested in the psychoactive drug scene and he was only at college for a semester. Immediately after he began to synth LSD in a little bathroom lab.

This I found interesting because it says he dropped out when he became interested in the psychoactive drug scene and he was only at college for a semester. Immediately after he began to synth LSD in a little bathroom lab.

yeah well, that was back when ordering huge quantities of raw lysergic acid (which is what he did) didnt raise an eyebrow, and neither did anything else needed for the easiest, most straightforward synth.
now im not saying he wasnt a great chemist, because as time went on he had to adapt and do it other ways etc.

must be a trip knowing that you basically fueled the 60's.

you think stupid noob had all his chem knowledge forced down his throat? no, he learned it on his own accord because he has a goddamn passion for it. if you can maintain motivation and ambition then you can teach yourself just about anything.

HAHA I think it's so funny that most people hate stupid cunt because he is a known gay/asshole but this fucking troll sticks up for him..lulz.

HAHA I think it's so funny that most people hate stupid cunt because he is a known gay/asshole but this fucking troll sticks up for him..lulz.

you are unbelievably retarded and gay. you did not discover anything, i am not SN, so don't think you're smarter than you really are. and if you actually found that funny then you should consider working on your sense of humor because it's seriously fucking lacking.

now i know you are obviously a goddamn autistic freak, so i won't hold much against you, but holy SHIT you are one STUPID son of a FUCK. go fuck a fat bitch or something you worthless shitbrain moron cuz i don't wanna see your bullshit on here again unless you miraculously wise the fucking hell up and stop acting like a 12 year old nigger fag fueled with ADHD

you are unbelievably retarded and gay. you did not discover anything, i am not SN, so don't think you're smarter than you really are. and if you actually found that funny then you should consider working on your sense of humor because it's seriously fucking lacking.

now i know you are obviously a goddamn autistic freak, so i won't hold much against you, but holy SHIT you are one STUPID son of a FUCK. go fuck a fat bitch or something you worthless shitbrain moron cuz i don't wanna see your bullshit on here again unless you miraculously wise the fucking hell up and stop acting like a 12 year old nigger fag fueled with ADHD

speakin of 12 year olds...

SYNTHESIS : A solution of 6.7 g KOH in 100 mL H2O, under an inert atmosphere and magnetically stirred, was brought to 75 °C, and 10 g ergotamine tartrate (ET) added. The reaction mixture turned yellow as the ergotamine went into solution over the course of 1 h. The stirring was continued for an additional 3 h. The reaction mixture was cooled to about 10 °C with an external ice bath, and acidified to a pH of about 3.0 by the dropwise addition of 2.5 N H2SO4. White solids started to appear early in the neutralization; approximately 60 mL of sulfuric acid was required. The reaction mixture was cooled overnight, the solids removed by filtration, and the filter cake washed with 10 mL Et2O. The dry solids were transferred to a beaker, suspended in 50 mL 15 % ammonia in anhydrous ethanol, stirred for 1 h, and separated by decantation. This extraction was repeated, and the original decantation and the second extract combined and filtered to remove a few hundred milligrams of unwanted solids. The clear filtrate was stripped of solvent under vacuum, the residual solids dissolved in 50 mL of 1% aqueous ammonia, and this solution was acidified as before with 2.5 N H2SO4. The precipitated solids were removed by filtration and washed with Et2O until free of color. After drying under vacuum to a constant weight, there was obtained 3.5 g of d-lysergic acid hydrate, which should be stored in a dark, sealed container.

A suspension of 3.15 g d-lysergic acid hydrate and 7.1 g of diethylamine in 150 mL CHCl3 was brought to reflux with stirring. With the external heating removed, there was added 3.4 g POCl3 over the course of 2 min, at a rate sufficient to maintain refluxing conditions. The mixture was held at reflux for an additional 5 min, at which point everything had gone into solution. After returning to room temperature, the solution was added to 200 mL of 1 N NH4OH. The phases were separated, the organic phase dried over anhydrous MgSO4, filtered, and the solvent removed under vacuum. The residue was chromatographed over alumina with elution employing a 3:1 C6H6/CHCl3 mixture, and the collected fraction stripped of solvent under hard vacuum to a constant weight. This free-base solid can be recrystallized from benzene to give white crystals with a melting point of 87-92 °C. IR (in cm-1): 750, 776, 850, 937 and 996, with the carbonyl at 1631. The mass spectrum of the free base has a strong parent peak at mass 323, with sizable fragments at masses of 181, 196, 207 and 221.

This base was dissolved in warm, dry MeOH, using 4 mL per g of product. There was then added dry d-tartaric acid (0.232 g per g of LSD base), and the clear warm solution treated with Et2O dropwise until the cloudiness did not dispel on continued stirring. This opaqueness set to a fine crystalline suspension (this is achieved more quickly with seeding) and the solution allowed to crystallize overnight in the refrigerator. Ambient light should be severely restricted during these procedures. The product was removed by filtration, washed sparingly with cold methanol, with a cold 1:1 MeOH/Et2O mixture, and then dried to constant weight. The white crystalline product was lysergic acid diethylamide tartrate with two molecules of methanol of crystallization, with a mp of about 200 °C with decomposition, and weighed 3.11 g (66%). Repeated recrystallizations from methanol produced a product that became progressively less soluble, and eventually virtually insoluble, as the purity increased. A totally pure salt, when dry and when shaken in the dark, will emit small flashes of white light.
LSD is an unusually fragile molecule and some comments are in order as to its stability and storage. As a salt, in water, cold, and free from air and light exposure, it is stable indefinitely. There are two sensitive aspects of its structure. The position of the carboxamide attachment, the 8-position, is affected by basic, or high pH, conditions. Through a process called epimerization, this position can scramble, producing isolysergic acid diethylamide, or iso-LSD. This product is biologically inactive, and represents a loss of a proportionate amount of active product. A second and separate point of instability is the double bond that lies between this 8-position and the aromatic ring. Water or alcohol can add to this site, especially in the presence of light (sunlight with its ultraviolet energy is notoriously bad) to form a product that has been called lumi-LSD, which is totally inactive in man. Oh yes, and often overlooked, there may be only an infinitesimal amount of chlorine in treated tap water, but then there is only an infinitesimal amount of LSD in a typical LSD solution. And since chlorine will destroy LSD on contact, the dissolving of LSD in tap water is not appropriate.

There are many synthetic methods developed and reported for the preparation of LSD. All of them start with lysergic acid, and for that reason it has been listed as a Schedule III controlled drug, as a depressant, under Federal law. The amide lysergamide, a component of several varieties of morning glory seed, is also a controlled drug and, by law, a depressant. The earliest syntheses of LSD involved the used of an azide intermediate (the original Hofmann process, 1955), mixed anhydrides with trifluoroacetic anhydride (1956) or sulfuric anhydride (SO3-DMF on the lithium salt, 1959), with the peptide condensation agent N,N'-carbonyldiimidazole (1960), or with the acid chloride as the active intermediate with POCl3, PCl5 or thionyl chloride (1963) or just phosphorus oxychloride (1973). Most methods are faulted due to excessive moisture sensitivity, generation of side-products, or epimerization or inversion at the 8-position carbon to form d-iso-LSD. The POCl3 procedure is clean and fast, and is the preferred process today for the synthesis of a wide variety of substituted lysergamides.

The term LSD comes from the initials of the German for lysergic acid diethylamide, or Lysersäure Diethylamid. The number "25" following it has many myths attached to it, such as it was the 25th form of LSD that Hofmann tried, or it was his 25th attempt to make LSD. From my own experience with chemical companies that are allied with pharmaceutical houses, I had assumed that the chemical name (which might be a mouthful for the pharmacologist) was simply replaced with a pronounceable code number equivalent. But the answer here is yet simpler. Hofmann, in his LSD, My Problem Child wrote: "In 1938, I produced the twenty fifth substance in a series of lysergic acid derivatives: lysergic acid diethylamide, abbreviated LSD-25 ... for laboratory usage."

Within a few years of the discovery of the extraordinary potency of LSD, a large number of close analogues were synthesized by Hofmann and his allies at Sandoz. Over the following decade many were tested in humans, both in patients and healthy subjects, with the qualitative descriptions and dosages published in the medical literature.

A number of analogues of LSD have maintained the diethylamide group unchanged, but additions or changes have been made in the pyrrole ring.

--indole-ring substituent--
at N-1 at C-2 Code
-H
-COCH3
-CH3
-CH2OH
-CH2N(CH3)2
-H
-H
-CH3
-CH3 -H
-H
-H
-H
-H
-B
-I
-Br
-I LSD-25
ALD-52
MLD-41


BOL-148

MBL-61
MIL

ALD-52. 1-Acetyl-N,N-diethyllysergamide. This material has been explored in the 50-175 microgram range and there are a number of human trials reported, with varying conclusions. One found that there was less visual distortion than with LSD and it seems to produce less anxiety and was somewhat less potent than LSD. Another report claimed it was more effective in increasing blood pressure. Yet another could not tell them apart. ALD-52 just may have been the drug that was sold as "Orange Sunshine" during the "Summer of Love" in the late '60's. Or "Orange Sunshine" may have been, really, LSD. This was the focus of a fascinating trial where two defendants were accused of distributing LSD, whereas they claimed that it was ALD-52 which was not an illegal drug. The prosecution claimed that as it hydrolyses readily to LSD, for all intents and purposes it was LSD, and anyway, you had to go through the illegal LSD to get to ALD-52 by any of the known chemical syntheses. The defendants were found guilty. And yet, I do not know who has actually measured the speed or ease of that reaction. If ALD-52 hydrolyses so easily to LSD, and the body is indeed a hydrolytic instrument, then these two drugs should be absolutely equivalent in every particular, This is the ergot equivalent of the psilocybin to psilocin argument, except this is an acetamide rather than a phosphate ester.

MLD-41. 1-Methyl-N,N-diethyllysergamide. The 1-methyl homologue of LSD is has more of somatic than sensory effect, has fewer visuals and is less well accepted than LSD, with the range of dosages being from 100 to 300 micrograms. This indicates that it is perhaps a third the potency of LSD which is in accord with both pupilary dilation and reflex action. However, the cardiovascular responses are actually increased. Besides being less potent than LSD, it appears to have a slower onset but it is equally long lived. There is cross-tolerance between MLD-41 and LSD.

BOL-148. 2-Bromo-N,N-diethyllysergamide. This synthetic ergot derivative, along with its 1-methyl homologue MBL-61 (mentioned below) should be used as powerful tools for studying the mechanism of action of LSD in the human animal. It does not have LSD-like effects in man. At 6 to 10 milligrams orally, there are some mental changes noted. But in another study, 20 milligrams was administered a day to a subject for 7 days, and there were no reported effects. And yet it is as potent a serotonin agonist as is LSD. How can serotonin be argued as a neurotransmitter that is a major player in explaining the action of psychedelic drugs, when this compound is nearly without activity.

There are some suggestions that an intervenous route may be more effective. I have heard of effects being noted at maybe a milligram and a short (2-3 hour) intoxicaion following 20 milligrams administered over a 20 minute period. I was involved many years ago in a study of radio-labelled BOL-148 which was made by the bromination of LSD. I was quite sure that the only radioactive material present was BOL-148, but there could well have been some unreacted LSD still present which would, of course, still be psychoactive. The synthesis is not clean -- I was tempted to make an entry for this compound if only to reproduce Albert Hofmann's original published experimental procedure. He reacted 13.2 grams of N-bromosuccinimide (in 400 mL dioxane, with 1.2 liters of dioxane containing 25 grams of LSD. This gave 11 grams of crude produce which had to be recrystallized. The radioactive syntheses uses effectively elemental bromine, and gave yields of from 5 to 15%. Visualize that reaction! A warm flask containing over a quart of warm solvent in which there was maybe half a million doses of LSD.

1-Hydroxymethyl-LSD, 1-dimethylaminomethyl-LSD and 2-iodo-LSD. These three additional compounds are shown here because they were described in a synthetic flurry that followed the discovery the activity of LSD. But at the moment I know neither their internal Sandoz codes nor if they had ever been explored in man. This is a kind of frustrating catch-all entry, in that the long index will send you here, and once here you realize that nothing is known. Well, at least the compounds are known, and perhaps there is something in the Sandoz vaults that might be interesting. I do not have access to them.

12000char

Dude if you can find that much toothpaste and orange peels it's super easy.

Why synth at that point when you can just scrape the orange peels add toothpaste and bake in the oven to make OTP? Punch that shit in a bong and you're fucking set.

I agree with distortion on this. You don't need formal education as long as you have the knowledge / experience on your own. This seems obvious to me but I guess a lot of people still believe the age old school iz t3h onry weigh peaple lern!

I was about to say this nigga. There was a good article over at the shroomery about his life.

Nigga dropped out of Princeton! IIRC.

If LSD was as easy to make as meth (as some people are almost stating) then LSD would be everywhere. Likely there only exists a couple LSD labs in the world currently.

Jesus fuck, i do not understand any of this :o

or develop terrible migraines...

or develop terrible migraines...

Yeah, that or get super high.

"The DEA claims their Santa Fe lab typically produced about 1 kilogram or 2.2 pounds of pure LSD, about 10 million doses with a street value of $100 million, every five weeks."

*squeals with joy*

Dude hows that a good thing? Imagine how much acid we'd have if that thing was still in operation. Distributing that much acid can't be easy though.

Dude hows that a good thing? Imagine how much acid we'd have if that thing was still in operation. Distributing that much acid can't be easy though.

Imagine if you could make that much every 5 weeks...
you could work 12 weeks then retire billionare and have enough cid left to last
you and everyone else on your block for a lifetime

you think stupid noob had all his chem knowledge forced down his throat? no, he learned it on his own accord because he has a goddamn passion for it. if you can maintain motivation and ambition then you can teach yourself just about anything.

Except vacuum energy.

Imagine if you could make that much every 5 weeks...
you could work 12 weeks then retire billionare and have enough cid left to last
you and everyone else on your block for a lifetime

Again, just because it has a street value of 100 million doesn't mean you can get 100 million for it. Actually I'm guessing he'd be lucky to to get half a million for it. Distributing 10 million doses of LSD is 200 times harder then making 10 million doses.

Past tense. :(:(

Fuck, imagine the one-way trip you'd get if you drank 2.2 pounds of pure LSD, one fucked up way to die.

My friend keeps telling me he is going to make DMT from lemon juice and grass, he read it on the internet, probably from totse.

it would help to have hands

yes, yes indeed it would.....

Obviously chemists but

I was thinking more of looking at a specific demographic. i.e. old guys

(-.-) i really dont like the way it sounds....

but then again if the person can cook up LSD-25 im sure he/she is not some stoned ass hippy not fully understanding the gravity of the situation.

The feds fears mass LSD approximately on the same level as a nuclear war.

My friend keeps telling me he is going to make DMT from lemon juice and grass, he read it on the internet, probably from totse.Probably thinking of a/bing DMT from phalaris.

A losing venture.

(-.-) i really dont like the way it sounds....

but then again if the person can cook up LSD-25 im sure he/she is not some stoned ass hippy not fully understanding the gravity of the situation.

The feds fears mass LSD approximately on the same level as a nuclear war.

Well dude, look at how badly the govt got pwnd during '64 rebellions. LSD was ["making"] the people see that the govt was screwing us, so everybody rioted. You basically had a riot/ "civil uprising" in almost every major eastern city in the US and also the The Sunset Strip curfew riots in LA

you think stupid noob had all his chem knowledge forced down his throat? no, he learned it on his own accord because he has a goddamn passion for it. if you can maintain motivation and ambition then you can teach yourself just about anything.

Oh man, that really made my day. It's kind of funny, seeing something so awesome and inspiring coming from you. You should really post like this more often :(.

Yeah, that had nothing at all to do with the political climate at the time. It was because of the drugs.

You have never made LSD-25 and it is not as simple as you think.



...No shit.

I thought it was blatantly obvious that I was being sarcastic?

Meta's no retard though...So I'll just have to chalk one up for natural human error rather than dumbfuckedness.

...No shit.

I thought it was blatantly obvious that I was being sarcastic?

Meta's no retard though...So I'll just have to chalk one up for natural human error rather than dumbfuckedness.

Agreed. He either understands the sarcasm you are trying to imply and is being sarcastic OR is you know.

I live 30 mins away from santa fe and I had NOOO idea this cat was doing this shit back in the day!

I live 30 mins away from santa fe and I had NOOO idea this cat was doing this shit back in the day!

STFU.. noob

And :
http://en.wikipedia.org/wiki/Owsley_Stanley

Was he the sound guy or something for the dead? and did he make a bunchof gold steal your face belt buckles, cause i got one and its leigit and i want to know how much its worth?

EDIT!!!! i just looked that shit up and i found a bronze one thats worth 700 bones, so my gold one has got be throughthe fucking roof, damn i just thought you all would enjoy that little discovery

your strange as fuck.

It may not be extremely easy...but you don't have to have a college degree to do it...trust me

There are way more than a couple in Texas lol

Me and a couple freinds tried once but we fucked it uo because we really only had a small grasp of organic chemistry andwhat we were doing. it would have yeilded less than 1oz of product anyway.

lol you can't even spell yield properly, you think an oz of lsd is not a lot, and you think an lsd synth is something to play around with in the garage with your friends.


FAIL

There are way more than a couple in Texas lol

Please tell me more.

have you ever been anywhere near austin? all i can say is damn

Considering you can smuggle a million hits of LSD with fedex, it doesn't mean anything that a lab might be present in austin.

Agreed. He either understands the sarcasm you are trying to imply and is being sarcastic OR is you know.

a dumbass?




I think yes.

Well let's just tell everyone we make acid, shall we?

Delete that then I'll delete this. Not smart at all.

lol you can't even spell yield properly, you think an oz of lsd is not a lot, and you think an lsd synth is something to play around with in the garage with your friends.


FAIL

I cant spell for shit when Im high, and I just admited we had no clue what we were doing, no need to be so harsh.

I cant spell for shit when Im high, and I just admited we had no clue what we were doing, no need to be so harsh.

Just curious, but what did you do specifically? Did you start with LSA?

Just curious, but what did you do specifically? Did you start with LSA?

its been so long i cant remeber, I wasnt really the best chemist back then for anything but pyrotechnics. the only thing i really remebered is that we failled is because we couldnt control the temperature properly.

its been so long i cant remeber, I wasnt really the best chemist back then for anything but pyrotechnics. the only thing i really remebered is that we failled is because we couldnt control the temperature properly.

lies.

Then again, you might have been on 1oz of acid.

ahahahaha.

dumbfuck.

I cant spell for shit when Im high, and I just admited we had no clue what we were doing, no need to be so harsh.

No need to be such an ignorant piece of shit lying faggot either.

http://www.bluelight.ru/vb/archive/index.php/t-256613.htm
this happened at the park i play disc golf at

if you are interested in synthesising LSD, this the type of stuff you should be able to perform.

Synthesis of Lysergic Acid,
By reacting N-benzoyl-3-(B-carboxyethyl)-dihydroindole for the preparation of this compound) with thionyl chloride, followed by aluminum chloride gives l-benzoyl-5-keto-l,2,2a,3,4,5-hexahydrobenzindole. This is then brominated to
give the 4-bromo-derivative, which is converted to the ketol-ketone by reacting with methylamine acetone ethylene ketol. This is then hydrolized by acid to yield the diketone and treated with sodium methoxide to convert it to the tetracyclic ketone. Acetylate and reduce this ketone with sodium borohydride to get the alcohol, which is converted to the hydrochloride form, as usual. The above hydrochloride is treated with thionyl chloride in liquid sulfur dioxide, to produce an amorphous chloride hydro chloride, which is converted to the nitrile with sodium cyanide in liquid hydrogen cyanide, Methanolysis then gives the ester of the nitrile. Alkaline hydrolysis of this last compound, followed by catalytic dehydrogenation in water using a deactivated Raney Nickle catalyst gives dl-lysergic acid.


as a side note, about 1 gram of purified LSD has the potential to contain about 6,000 to 10,000 doses, about $30,000 these days. If whoever it was who said they made an ounce of the stuff wasnt lying, then you wouldve been set if you sold it the right way.

Yeah, 1 oz of LSD is not a lot at all.

No need to be such an ignorant piece of shit lying faggot either.

I don't understand the psychology behind why people lie like this. Even in day to day conversations with people I always can tell the bullshit lies people put forth, which don't seem to serve any purpose. They may say them to seem cool, but the coolness they could possibly gain cannot outweigh the chance of being caught and looked down upon right? It just doesn't make any sense.

Disk golf FTW!

Well let's just tell everyone we make acid, shall we?

Delete that then I'll delete this. Not smart at all.

Well being that I HAVE a college degree, that statement would not apply. How I know you don't have to have a college degree is as simple as this: They busted a lab around here that was run by someone who had never attended college.

JESUS FUCKING CHRIST!!!

THIS THREAD IS ALMOST A MONTH OLD...

Fuck you acolyte.

Well obviously I have better things to do than sit on here all day :-)

HOLY SHIT. I go to White Clay all the damn time for walks and bike rides. 5 minutes from my house.

HOLY SHIT. I go to White Clay all the damn time for walks and bike rides. 5 minutes from my house.

no one gives a shit you dumbass

This thread is filled with a lot of brain-less bitching and bickering back and forth, overall quite reckless and chaotic.

Frankly, reading through this thread was quite damaging to the eyes and disturbing to the mind...

Anyhow I come to ease the tension and provide you with - http://www.youtube.com/watch?v=C2BiLuBsN08&feature=related ;)

By the way, wtf has been going on here @ bltc lately, every fuxking thread is either a brain-less topic that has been given absolutely NO thought, or the responses within the thread are completly unhelpful trollish / flames ... has this place really expired ... eh fuxk it..

.peace.

Past tense. :(:(

Shit brings a tear to my eye...

Molosh want...:(

You don't need a degree to synthesise acid, I don't think anyone ever really meant that. What you do need is an excellent grasp of organic chemistry and excellent lab technique - LSD synthesis is [i]way[/] beyond meth or MDMA is terms of conceptual difficulty, practical difficulty and the difficulty in sourcing your starters.

Also, no-one's mentioned Richard Kemp or Operation Julie yet... These guys supplied 90% of the world's LSD in the 70s... Good read !

Yeah i thought it was just a phase but it seems not to be going away huh........

Also if anyone on totse WERE to synth LSD, i doubt theyd be stupid enough to contemplate it here... Let alone admit they do it. I think its a bit out of reach of most totseans, not saying certain people on here wouldnt know what they were doing...

And, please don't bitch, is it possible if you had the time to teach yourself the entire proper LSD synthesis and if you had money to pull it off?

Actually, it's one of the best-kept secrets that it's one of the easiest synths out there - at least if you're not starting from tryptophan, which I proposed an unfounded hypotheosis for in LT once...

'n that secret is pretty much going to stay well-kept.

Half of the synthesis that Shulgin described, that gets quoted in each of these threads, has already been posted on &t in one forum. The other half of said synthesis, as Shulgin describes it, has been posted in another. Neither of these threads were in Shulgin's own words, neither discussed LSD, and for that matter, I have pretty good faith that none of the people involved in any of the threads were intending to make LSD in any way connected with any of the posts.

How hard is it to teach one's self? Several people already have. They just didn't know it could be used for that.

When you can read the good Dr.'s annoyingly terse synthesis descriptions and completely rewrite them to suit your needs, you will be ready, grasshoppa. Is it possible? Very possible. Could you learn? Certainly, if you chose to learn. It wouldn't even be hard.

Just a little secret your corporate-governmental complex doesn't want you to figure out : everything that was ever done on this earth was done by a human being. That means you can do it. 'n in those cases where it doesn't hurt much to try (which an LSD synth might not be, but in the general sense) - why not do it for shits 'n giggles? 'n everything else can be done too.

Have fun.

no one gives a shit you dumbass

I guess telling me in IRC wasn't enough for you? Fuck off distortion.

LSD from Lysergic Acid
and S03
This is the second of the two excellent methods of LSD synthesis. It
gives very good yields of high-quality product, if two precautions are
followed. The first point on which success hinges is the
requirement that a rather strict stoichiometry (stoichiometry concerns
the proportions of different chemicals used in reactions) be followed in
both the amount of alkali reacted with the lysergic acid to form the salt
of lysergic acid, and the amount of SOs then added to form the mixed
anhydride of lysergic acid.
The other key precaution is the need to maintain strictly
anhydrous conditions in both the production of the SO3-solvent
complex, and the reaction of that complex with the lysergic acid salt to
produce the mixed anhydride. The reason for this is that SOs is the
anhydride of sulfuric acid, and any traces of moisture will react with it to
produce sulfuric acid. Sulfuric acid does not react with lysergic acid
to form an anhydride. Instead, it just messes up the stoichiometry of the
reaction, leading to greatly reduced yields.
To prevent moisture from interfering with the reaction, glassware
should be baked in an electric oven for an hour or so, and then
allowed to cool down in a dessicator. High humidity must be avoided, so
this is not work suitable for a damp basement or even reasonably
Practical LSD Manufacture
48
humid days. Air conditioning, or winter's dry indoor heated air are
best. Solvents and reagents must be free of water. The reaction works as
follows:
Preparation of Sulfur Trioxide Complex
Work begins with the preparation and standardization of SOssolvent
complex. SOs is available from a couple of sources. There is a
6 LSD From Lysergic Acid And SO}
49
form of pure stabilized SOs called Sulfan B. If this material can be had
off of some unguarded shelf, it is superior to the other source of SOa,
fuming sulfuric acid.
To make the SOs-solvent complex using Sulfan, a 2000 ml flask is
charged with a magnetic stirring bar and 1000 ml acetonitrile.
Dimethylformamide can also be used as the solvent, but the authors of
the patent for this process evidently preferred acetonitrile for the
production of LSD. The solvent should come from a freshly-opened
bottle made by a reputable manufacturer. The bottle will list the water
content, generally a few-hundredths percent. This amount of water
will not pose a problem.
Next, the flask is fitted with a condenser and a dropping funnel,
both being equipped with a drying tube to prevent the atmospheric
moisture from infiltrating the reagents. The flask is nestled into a
plastic or Styrofoam tub containing ice water, and the solvent allowed to
cool down. When the temperature in the flask gets down to 5- C,
stirring is begun, and 40 grams of Sulfan should be put into the
dropping funnel. The Sulfan should be dripped into the solvent slowly
and cautiously over a period of an hour or two, while maintaining the
temperature inside the flask in the 0-5° C range. A crystalline
precipitate may form during the addition. If it does, continue stirring
for another hour or so to bring it into solution. If it still fails to
dissolve, add more solvent. Acetonitrile-SOs complex is generally
used at a strength of .5 molar, while dimethylformamide-SOs complex is
used at 1 molar strength. 80 grams per liter SOs is 1 molar. Using
Sulfan fresh from the bottle, it is not necessary to analyze the strength of
the resulting SOs-solvent complex so long as complete dissolution is
achieved.
The procedure for making SO3-solvent complex from fuming
sulfuric acid is more complicated, but less likely to arouse suspicion
since fuming sulfuric acid has a lot more uses than Sulfan. It is also far
more likely to be available via the five-finger discount method.
Fuming sulfuric acid comes in a variety of strengths, but the ACS
reagent contains 30% SO3 or oleum. Pure SOs boils at 45° C, and at
room temperature has a vapor pressure of over 400 mm Hg. That is
Practical LSD Manufacture
why the stuff fumes, and why the stuff can be removed from the
sulfuric acid in which it is dissolved. A simple although timeconsuming
method for preparing SOa-solvent complex from fuming
sulfuric acid is to use an adapter such as the one pictured in Figure 2.
With all glass
ware thoroughly
dry, one can attach
a 1000 ml flask on
one side of this
adapter and put
500 ml of fuming
sulfuric acid in it.
figure 2 '— On
tne other side
of the adapter, a 2000
ml flask can be attached
containing 1000 ml of
acetonitrile or dimethylformamide. The use of stopcock grease
should be avoided, as SOs will attack it. Rather the joints should be
sealed by wrapping parafilm around them.
There will be a tendency for the two solutions to come into a
vapor equilibrium. 30% oleum contains about 580 grams per liter
SOa. The vapors will over time work their way into the solvent and
form complexes. It will take some time, depending upon the
temperature, for enough fumes from the sulfuric acid to work their
way out of the acid and into the solvent. Slow magnetic stirring in the
solvent helps to maintain a homogenous mixture, and speeds
absorption of SOa fumes. Cooling the solvent in ice can't hurt either.
Analysis of the solvent should be done after about 12 hours have
passed. The need for stirring is especially crucial here so a
representative sample is taken. To analyze, remove exactly 2 ml of
solvent with a pipette and squirt it into 50 ml of distilled water. Add
some phenolphthalein indicator, or monitor pH with a meter. Now
titrate with .IN NaOH (prepared by dissolving exactly 4 grams of
NaOH pellets in one liter of water) until the color of the solution turns
50
Adapter used in preparing SOj-solvent complex
from fuming sulfuric acid.
6 LSD From Lysergic Acid And SO3
51
pink, or the pH meter shows pH 7. Record the amount of NaOH
solution used.
Molarity SO, in solvent = mis NaOH used / 40
So a 1-molar SO3 complex will require 40 ml of .IN NaOH to
neutralize it. Two equivalents of NaOH react per sulfuric acid.
If after 12 hours, the solvent has still not absorbed enough SO),
just let the process continue. The complex formed need not be exactly
.5M in acetonitrile, or 1 M in dimethlyformamide, just close to those
values. What is important is that the exact strength of complex formed
be known, because that dictates just how much of SOa solution is
used. That is crucially important to the success of the reaction.
When the SOa-solvent complex has reached the desired strength,
the flask containing it should be stoppered with a glass or Teflon
stopper, and kept in the fridge. It will gradually darken first to yellow
and then orange, but it is good for at least 3 or 4 months.
The argument can be made that this procedure is wasteful of
fuming sulfuric acid. After all, maybe only 2 liters of 1-molar SO3
complex can be reasonably made from a pint of fuming sulfuric acid
by this passive fume-absorption method. When one considers that this is
enough SO3 to make 3 million doses, however, such objections are silly.
Batch Production
With SO3 complex in solvent prepared and carefully standardized to
evaluate its exact strength, attention can be turned to LSD synthesis
using lysergic acid and SO3 complex. Exact weighing of ingredients,
and assuring that they are free from water are the two main concerns in
this synthesis. To that end, the lysergic acid crystals obtained by the
methods given in Chapter 5 should be dried without heating under a
vacuum for about an hour. This will remove all but the water of
crystallization, which poses no problem. The scale used to portion out
Practical LSD Manufacture
52
the ingredients for this synthesis should at least be a very sensitive
triple-beamer, and its accuracy should be checked using new
corrosion-free brass weight standards. Atmospheric humidity is a very
real threat. NaOH, KOH, and lysergic acid will all pull water from the
air. This not only makes accurate weighing impossible, but it also
introduces water to the batch. For this reason, air conditioning or the
dry indoor heat of winter are best during the unavoidable handling
and weighing of reagents.
Two methods will be presented here, the first being the specific
synthetic method for LSD given in example ten of US Patent
2,774,763. The other is the general method given in Journal of
Organic Chemistry Volume 24, pages 368 to 372. Both are authored by
William Garbrecht, a true hero of LSD synthesis. The patent dates from
1955, while the Journal article dates from 1958.1 leave it to the serious
experimenter to decide which is more advanced. No doubt, both are
operable.
Patent Method
15 grams of lysergic acid is quickly weighed out, and placed in a
dried 1000 ml flask equipped with a magnetic stirring bar. 200 ml of
methanol is added to dissolve the acid, then the flask is stoppered while
either 2.22 grams lithium hydroxide hydrate, or 2.09 grams sodium
hydroxide pellets or 2.94 grams KOH pellets is weighed out and
dissolved in 200 ml methanol. The use of lithium hydroxide is preferred
because it doesn't absorb water from the air, thereby messing up the
weighing. Lithium hydroxide, on the other hand, is not a very common
item, and will raise red flags that attract unwelcome attention.
NaOH and KOH, however, are very mundane items. Further, a
freshly opened bottle containing them can safely be assumed to be free
of water. Quick weighing under low humidity will not add appreciable
amounts of water to it. If the choice was mine to make, I would use
NaOH or KOH.
6 LSD From Lysergic Acid And SO3
53
The LiOH or NaOH or KOH solution is now added to the
methanol solution containing lysergic acid. After a period of stirring to
assure complete reaction to the metal salt of lysergic acid, the
solvent is distilled off under a vacuum, leaving a bubbly residue
clinging to the glass at the bottom of the flask. If the lysergic acid is
pure, such as that made by method 2 in Chapter 5, this residue will
have a glassy appearance. No heat stronger than steam or hot water
should be used to drive the distillation.
The residue in the flask still contains traces of water and
methanol. The water comes from the reaction of the hydroxide with
the acid, and from the lithium hydroxide, if that was used. This is
removed azeotropically. Add 500 ml of hexane to the flask, and distill
off about half of it, using a fractionating column. Both water and
methanol form azeotropes with hexane.
The approximately 250 mis of solution left in the flask is now
cooled in an ice bath to about 5° C. When that temperature is reached, . 1
mole of SOa-acetonitrile complex is added. If the solution prepared is .5-
molar strength, that requires the addition of 200 ml. This
addition should be done with strong magnetic stirring, and slowly
enough that the temperature does not climb too much. After the SOa
has been added, allow the reaction to come to completion for about 5
minutes, then add 18 grams of diethylamine (26 ml) dissolved in 250
ml of anhydrous ether.
A further 5 minutes of reaction time is then allowed with stirring,
before pouring the whole reaction mixture into a 2000 ml sep funnel.
Now 1000 ml of water is slowly poured into the sep funnel with
swirling. This addition of water generates a lot of heat as the SOs
reacts to make sulfuric acid, and then gets diluted. Over a period of
time work up to shaking the sep funnel. The LSD goes into the water
layer. Separate it off, and extract four more times with 1000 ml
portions of water.
The combined water extracts (5000 ml in all) are now saturated
with salt, then extracted five times with 1000 ml portions of ethylene
dichloride (1,2-dichloro-ethane). Ethylene dichloride is heavier than
water, so it forms the lower layer in the sep funnel.

^^^^ You didn't finish .

With the exception of few you should all go kill yourself because you have no fucking clue what your talking about. Go learn some proper chem and then make another thread or even attempt to post in a thread about LSD, until then kindly GTFO.

Thats it all,

niggers

:)

you are unbelievably retarded and gay. you did not discover anything, i am not SN, so don't think you're smarter than you really are. and if you actually found that funny then you should consider working on your sense of humor because it's seriously fucking lacking.

now i know you are obviously a goddamn autistic freak, so i won't hold much against you, but holy SHIT you are one STUPID son of a FUCK. go fuck a fat bitch or something you worthless shitbrain moron cuz i don't wanna see your bullshit on here again unless you miraculously wise the fucking hell up and stop acting like a 12 year old nigger fag fueled with ADHD

What a faggot holy shit.
Go suck stupid noob's cock you fucking queer.

CHILL. You didn't even read my original OP. I just was wondering about who and what kind of people synth LSD, not instructions on how to. I also asked how hard it would be to teach oneself (not me, I'm fucking 15). So shut the fuck up and read.

I honestly don't know, but I always tell idiots that ask me as if I do that it's one of the hardest things to do and only genius's can do it.
I hate it when someone stupid asks me anything about lsd..

Actually, it's one of the best-kept secrets that it's one of the easiest synths out there - at least if you're not starting from tryptophan, which I proposed an unfounded hypotheosis for in LT once...

'n that secret is pretty much going to stay well-kept.



Aw come on man, were totse (more importantly BLTC), its like family here!