Considering that the multiple uses of the DLPA cocktail have destroyed my friends tolerance to marijuana, and possibly cocaine, what would happen if he were to take 80mg of pure MDMA with some amount of caffeine?

Would doublemassive euphoria ensue or could it potentially be dangerous? Are there any necessary precautions?

Also, how long do the effects of these cocktails last?

Check the original thread, there's something about dopamine and serotonin competing for some mumbo jumbo that i couldn't be fucked looking for. :)

"Hey - you got hydrogen peroxide in my raephe nucleus!!!"

"Hey!!! You got brain goo in my hydrogen peroxide!!!!!!"

heh...

The current model of serotonin-release neurotoxicity tends to resolve around dopamine getting sucked into the (now basically empty) serotonergic axon by the serotonin reuptake transporter...

Now, normally, this only happens with dosages in excess, or with some of the more brutal empathogens, such as the non-fluro-parahaloamphetamines.... though millions of stupid raver kids have, in fact, discovered that "dosages in excess" is in fact a synonym for human stupidity - whether by munching the shit with an alcohol-culture mindset untill they're two grams into rolling each other under the table, or whether they're trying to use MDMA (or, god knows what) as coffee to stay up for a week... but, subtracting idiocy from the equation, it's a minor and limited risk with occasional use.

...but... as you might be guessing, dumping peroxide generators in gram weight on the serotonergic-release empathogen peroxide glitch... might not be the best idea. This is true of endosynthesis of dopamine, and yes, it also suggests that meth is in fact the most dangerous and destructive MDMA cut possible, rather than JUST being the most common MDMA adulterant everywhere...

There are ways around this, of course; the peroxide scrubbers, tried, true, and tested, are listed in a wide swath of MDMA/PCA journal refs. Apparently, science as a whole is fascinated by the notion of rolling safely, and who can blame them?

...but without them, mah favorite organ in the brain sort of goes "pfft" in a cloud of smoke, and I'd hate to be the one responsible for some fool misinterpreting the data and thinking that the vitamin C in a single orange slice once a week would be sufficient to drop a half gram of E, slam a ball of meth, and wash it up with a DLPA stack 2-5 minutes after administration every night for the rest of their life without consequences.

Not that having eaten a catecholamine generator within the same month/week/whatever is intrinsically a drastic contraindicator to MDMA... just that acute coadministration requires... certain precautions.

Also, how long do the effects of these cocktails last?

What level of effect with what stressor to reserve?

Zero effect, meaning that it is as if you had never taken it.

Probably about several months to true zero, but usually about 1-2 weeks to apparent-zero without testing storage variance with other drugs, which tend to pull stuff out of storage ya didn't even know ya had. ;)

...that estimate of course is based on zero unreasonable stressor; I'm sure a hearty meth binge could wipe it out to true zero in under a week.