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Better Living Through Chemistry Discussions of any and all sorts of mind-warping chemicals, pills, booze, mind machines, trippy stuff, current street prices, importing pharmaceuticals, smart drugs, nutrients, herbs, and altered states. Please try to keep your conversations "theoretical" in nature, since this is an open conference.

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 #1 
Old 2008-01-16, 03:58
DiamondX DiamondX is offline
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Default Oxycontin Release Rate?

I was wondering what the release rate for oxycontin is? I tried google already, but didn't find anything.
 #2 
Old 2008-01-16, 04:06
silverballs silverballs is offline
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Default Re: Oxycontin Release Rate?

I figure it's like taking 2 pills, one instant release and the other's coating dissolves around the time your coming down off the first one. :)
 #3 
Old 2008-01-16, 04:18
The Doc The Doc is offline
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Default Re: Oxycontin Release Rate?

I know what you are asking, but damn if I know.
Like, example: If you swallowed a 40mg Oxycontin controlled release pill, will 20mg be instantly released, then 5/10mg per hour afterwards? Right? This isn't your answer, but I did find this tidbit of info:
"One OxyContin 160 mg tablet is comparable to two OxyContin 80 mg tablets when taken on an empty stomach. With a high fat meal, however, there is a 25% greater peak plasma concentration following one 160 mg OxyContin tablet."
Wasn't the 160mg pill discontinued? I'm guessing this info is from the time when they were still around. Taken from: http://pharma-help.com/oxycontin

Peace.
 #4 
Old 2008-01-16, 04:38
robinhoody robinhoody is offline
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Default Re: Oxycontin Release Rate?

When in doubt, consult the prescribing information: http://www.purduepharma.com/pi/prescription/oxycontin.pdf

Start reading at the bottom of page 4.
 #5 
Old 2008-01-16, 05:42
The Doc The Doc is offline
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Default Re: Oxycontin Release Rate?

Quote:
Originally Posted by robinhoody
When in doubt, consult the prescribing information: http://www.purduepharma.com/pi/prescription/oxycontin.pdf

Start reading at the bottom of page 4.


You know, I came upon that same .pdf, but it didn't show up properly at first, only the first 2 pages, so I just disreguarded it. Oh well, new info :)

Peace.
 #6 
Old 2008-01-16, 22:27
DiamondX DiamondX is offline
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Default Re: Oxycontin Release Rate?

Quote:
Originally Posted by robinhoody
When in doubt, consult the prescribing information: http://www.purduepharma.com/pi/prescription/oxycontin.pdf

Start reading at the bottom of page 4.


Thanks

In contrast, OxyContin Tablets exhibit a biphasic absorption pattern with two apparent absorption half-lives of 0.6 and 6.9 hours, which describes the initial release of oxycodone from the tablet followed by a prolonged release.

So that means the half-life of the first bit of oxycodone that is released is 36 minutes, and the half-life of the extended release portion is about 7 hours?

The table on page 6 shows 10mg OxyContin to be almost identical to 5mg immediate release oxycodone, except the OxContin lasts 12 minutes longer than twice as long, and is ~4.6% stronger.
 
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