I swear, every drug user needs to have a box of these babies laying around, it's hard to find a class of drugs they DON'T improve...

That's right. According to THIS chart, we see that the substrate tetrahydrocannabinol(THC) is metabolized by enzyme CYP2C9.

We look further down, to the inhibitor section, and find that Cimetidine (Tagamet HB) is a significant inhibitor of this enzyme.

DAMN. This means that, when a large amount of Tagamet(600mg-800mg [3-4 pills]) is ingested ~45 minutes before smoking, the weed high SHOULD last significantly longer, and you should get higher as well.

While I haven't explicitly tested this yet, Some of you may remember a thread I had put together a while back describing a method of weed potentiation with large amounts of cocoa powder.

I had fantastic results, and got SUPER baked and for a longer period of time with just a bit of bud, but none of the people who tried experienced the same results.

Now I realize, while the anandamide and cannabinoid inhibitors present in cocoa may have helped a bit, I had taken 400mg of Tagamet HB an hour or two earlier. THIS must have been what caused such pronounced effects.

I hadn't put the two together until now.

This should be ESPECIALLY useful for pot brownies, or any other method of oral marijuana. This would completely get rid of or at least temporarily postpone(depending on Tagamet's length of action) the first pass metabolism. This means it would take SIGNIFICANTLY less weed to get baked, as first pass metabolism destroys some of THC.

(First pass metabolism only takes place when eaten, though)

I have no facts supporting this, but assuming I haven't made any logic errors, a mildly tolerant person could get super baked from a .3 gram pot brownie. (made with good shit)

So, before I go and take massive amounts of Tagamet in an attempt to make a smoked weed high last like 7 hours, do you guys see any immediate faults in my plans here?

Also, are there any known health complications of taking upwards of 1 gram of Cimetidine?

holy shit a thourally explained/researched idea with a legitmate point.

you blew my mind.

Yeah, thanks. I'm just glad I didn't post this last night like I was planning to.

Apparently in my sleep-deprived stupor, I missed Cimetidine on the inhibitor list, but miconazole caught my eye. It's the active ingredient in Monistat, an OTC vaginal cream. I was thinking that doing some kind of extraction on Monistat might yield pure miconazole, which is apparently a better CYP2C9 inhibitor than cimetidine.

However, I couldn't justify the idea of walking up to a counter and purchasing a bottle of puss cream, and was going to abandon the project, until I looked at it again today and noticed Tagamet on there.

Very nice discovery...

I'm glad you brought this up! This raises an interesting point...

*flips through merck manual*

Right!

CYP2C9 -

Substrates: Diclofenac, Phenytoin, Piroxicam, Tetrahydrocannabinol, Tolbutamide

Inhibitors: Sulfaphenazole, Sulfinpyrazone

Inducers: Rifampin


yeeup, just as I thought.

the internet > the merck manual



translation: good work, holmes!

holmes in the sherlock sense, not the mexican sense.

Remember, before you go experimenting with putting shit in your body, make sure you know what you're doing. Not that I sense any particular danger from this thread, but stating these things never hurts...

Of course.

Hmm, interestingly enough, as superior as the interwebs may be, Sulfinpyrazone isn't listed as an inhibitor for some reason...

In any case, I'm extremely eager to try this out, and probably will after I get off work.

FadedAllDay: Because you have such a large tolerance, you may not see as dramatic effects as someone with a moderate tolerance, but you should still notice a difference.

You can buy Tagamet HB at any pharmacy, over the counter. At the CVS near me it's $5.99 for a box of 50 200mg pills. I recommend taking 4 of those pills 45 minutes before smoking weed. Seriously, don't take them like 20 minutes before hand haha, time may be an important factor.

So yeah. Rite aid should have it, take 4. (but 45 minutes before smoking!!!)

EDIT:
It's elementary, Watson!

*Does a line of cocaine*
*Puffs on his namesake*

You'd think so...

***

I'm going to look for possible health risks from taking that much Tagamet. Would 300 mg or so still help? I don't smoke weed any more, but before I recommend this to my stoner friends I'd like to know if I'd be doing them a favor.

It might do SOMETHING, but not as much as if you were to completely bog down the enzyme.

Think of the enzyme like a valve on a hose, and the THC like water. Tagamet is the pressure you're applying to close the valve.

Assuming it's set to full blast, turning the hose just a little bit won't do much. Alot of water(THC) will still be coming out. Even if you turn it half way closed, there will still be a significant stream flowing. Only when you fully or almost fully (because you never really can fully turn off those damn garden hoses ) shut the valve will you start to notice less water on the lawn. Or the street. Or wherever your damn hose leads to.

With that far-fetched metaphor out of the way, I'll go on to say that there are prescription 600mg cimetidine tablets, so at the very least, 600mg is safe.

They also used to make OC 160s...

Well, that's slightly different, it's time released and only for opiate tolerant people. These 600mg cimetidine tablets are instant release and for everybody...

I mean:

dood they stil maek those, i hav 4 sitin on mi desk rite now!11

ya man i got a pile of quaaludes in front of me too.

I've got six grocery bags full of Seconal.

i dont see any major faults in your plans...

Toxicology of cimetidine

Im getting that shit today, when I go to CVS what will it be under?

It's the same as drinking grape juice before Dexing

possible side effects:

Abdominal pain; back, leg, or stomach pain; bleeding or crusting sores on lips; blistering, burning, redness, scaling, or tenderness of skin ; blisters on palms of hands and soles of feet; changes in vision or blurred vision; confusion; coughing or difficulty in swallowing; dark-colored urine; dizziness; fainting; fast, pounding, or irregular heartbeat; fever and/or chills; flu-like symptoms; general feeling of discomfort or illness; hives; inflammation of blood vessels; joint pain; light-colored stools; mood or mental changes, including anxiety, agitation, confusion, hallucinations (seeing, hearing, or feeling things that are not there), mental depression, nervousness, or severe mental illness; muscle cramps or aches; nausea, vomiting, or loss of appetite; pain; peeling or sloughing of skin; red or irritated eyes; shortness of breath; skin rash or itching; slow heartbeat; sore throat; sores, ulcers, or white spots on lips, in mouth, or on genitals; sudden difficult breathing; swelling of face, lips, mouth, tongue, or eyelids; swelling of hands or feet; swollen or painful glands; tightness in chest; troubled breathing; unusual bleeding or bruising; unusual tiredness or weakness; unusually slow or irregular breathing; wheezing; yellow eyes or skin

Constipation; decreased sexual ability (especially in patients with Zollinger-Ellison disease who have received high doses of cimetidine for at least 1 year); decrease in sexual desire; diarrhea; difficult urination; dizziness; drowsiness; dryness of mouth or skin; headache; increased or decreased urination; increased sweating; loss of hair ; ringing or buzzing in ears; runny nose; swelling of breasts or breast soreness in females and males; trouble in sleeping

Is allthis correct?

thanks for the well thought out post.

ok, so i went to cvs and dropped 11 fucking dollars on a pack of 30 200mg cimetidine tablets. it says to not take more than one at once or 2 in a day. is it ok to take four as you suggested?

Incidentally, expanding on your opi potentiation guide, any amount of DXM will kill a codeine high... it practically negates blood concentration...

holy shit it acctuly works! surprised the shit outa me

It seems to be working for me right now. I took 800 mg and smoked just over an hour later. Now I'm high as hell off of ~.3g of beast. I'll post later and tell you if the high is extended.

yeah just take a full gram (1000mg) wait 40 minutes then in my opinion vape it. (lightbulb vape) if you need to. That's what gave me the best results.


Vape>bong>bowl>joint>water bottle bong>apple pipe>putting it on a table and using your hands to catch the smoke>eating raw


no i havnt tried the last two

Lightbulb vapes fucking blow i don't even know why they are used, the last few times i've used them i've wondered whether or not i was high..

however, a real, legit vape is off the chain cool, but still not that effective.


plus the real effectiveness of this has yet to be really proven, it's hard to expect a high person to accurately remember the results..

but anyway, i, myself have noticed a difference in peak length, not really intensity or general length of the high.

still was worth the 10$ for something to fuck around with, but still, shoulda stole em.

peak length i s what its about. i'll go get some fuck it.

yeah if you don't use it right it fucking sucks...just like a nub trying to use a bong, yah know?

GUYS I JUST THOUGHT OF SOMETHING!!1

THC has a psychoactive metabolite (specifically, 11-hydroxy-THC). I was under the impression that this metabolite plays a role in making the pot brownies experience so much different from the high when smoked. Do you think this might make pot brownies more like smoking weed? What kind of effects could this have?

What's the ideal amount of time to wait after ingestion of the Tagamet before toking up?

40-45 mins is what everyone is saying. But i tried it for the first time a few days ago and it didn't do much.

Gona try again tmrw.

Still no luck with 1000mg of the shit. Maybe it's because im not vaping it, but fuck making a lightbulb vape.

http://www.drugs.com/pdr/tagamet-hb.html

Yea fuck that.

Fuck there are a lot of you dumb ass' that think light bulb vapes are all that. I knew it was a piece of shit when I was 13.

According to the chart, the breakdown of MDMA is also inhibited by taking this. Has anybody tried taking MDMA with Tagamet? Would anyone like to in the name of science?

Thats interesting...Im definitely willing to try it next time I roll, Ill do some research...

Btw - Keep in mind if you eat the Tagamet on even a mildly empty stomach, you should start smoking like 20-30 minutes after, if on an empty stomach I would smoke 10-20 minutes after ingestion...that's what has given me the best results.

mdma is in the column next to THC, in the column for a different enzyme so it shouldnt work. Am i missing something?

Yeah. The fact that cimetidine is also in the inhibitor category for that enzyme (and a few others) as well.

http://en.wikipedia.org/wiki/MDMA#Pharmacokinetics

But be careful, titrate your dosage and don't take too much of the inhibitor.