Opium exhibits not only the action of morphine but also the actions of codeine, papaverine and other alkaloids present in opium. The other alkaloids in opium alkaloids enhance the sedative and analgesic effects of morphine and tend to minimize its undesirable side effects. Pharmacokinetic data on opium alkaloids and their collective administration are not available; however, data are available on morphine, the major component of opium alkaloids.

Morphine acts as an agonist interacting with stereo-specific receptors in the brain and other tissues; the receptor sites are distributed throughout the CNS and are present in highest concentrations in the limbic system, thalamus, striatum, hypothalamus, midbrain and spinal cord. Morphine is well absorbed after subcutaneous and intramuscular administration.



Codeine is an alkaloid obtained from opium or prepared from morphine by methylation and occurs as white crystals. Codeine effloresces slowly in dry air and is effected by light.

The chemical name of codeine phosphate is 7,8-didehydro-4,5a-epoxy-3-methoxy-17-methylmorphinan-6a-ol phosphate (1:1)(salt) hemihydrate and has the empirical formula of C18H21NO3·H3PO4·½H2O



Codeine phosphate is freely soluble in water.

120 mg of codeine phosphate produces an analgesic response equivalent to that from 10 mg of morphine.



Morphine sulfate occurs as odorless, white, feathery, silky crystals, cubical masses of crystals, or white crystalline powder. It has a solubility of 1 in 21 parts of water and 1 in 1000 parts of alcohol, but is practically insoluble in chloroform or ether. The octal:water partition coefficient of morphine is 1.42 at physiologic pH and the pKb is 7.9 for the tertiary nitrogen (mostly ionized at pH 7.4).

The chemical name for morphine sulfate is 7,8-didehydro-4,5a-epoxy-17-methylmorphinan-3,6a-diol sulfate (2:1) (salt), pentahydrate.

The empirical formula is (C17H19NO3)2·H2SO4·5H2O.

Now these are the alkoloids found in the opium latex-gum.

And I figured it'd be proper to post their pharmakinetics and whatnot.

I'm gonna break this up into seperate posts.

Next I'll outline opium->morphine--->diactylmorphine(heroin)



Jam.

anxiously awaiting next post!

Ratios to bare in mind-->Opium is 10-30%-Morphine.

16 ounces of Morphine will reduce to 11 ounces of heroin. 16/16ths:11/16ths

Most opium these days is pushing the 25%'tiles.



This I followed using 3000-grams/3-kilos

Which I did but this has not been scaled down to a nano proportion but I see no reason a nano wouldn't work. Aftr I completed this Journey I ended up with almost to the letter the usual expected net-yields found in the labs of Afghanistan/Burma/Sicily etc.



High-quality raw opium will be brown (rather than black) in color and will retain its sticky texture.

The process of extracting morphine from opium involves dissolving opium in hot water, adding lime to precipitate the non-morphine alkaloids and then adding ammonium chloride to precipitate the morphine from the solution. Water and some cooking pots are all that is needed.

1. Bring to a boil the same amount of water you would use for cooking spaghetti. Tap water is not a problem here.

2. With stirring, the raw opium eventually dissolves in the boiling water, other non-soluble materials float in the solution. Most of these materials are scooped out of the clear brown 'liquid opium' solution.

3. Slaked lime (calcium hydroxide), The lime converts the water insoluble morphine into the water soluble calcium morphenate. The other opium alkaloids do not react with the lime to form soluble calcium salts. Codeine is slightly water soluble and gets carried over with the calcium morphenate in the liquid. For the most part, the other alkaloids become part of the residual sediment 'sludge' that comes to rest on the bottom of the pot.

4. As the solution cools, and after the insolubles precipitate out, the morphine solution is scooped from the pot and poured through a filter of some kind. I reccommend a tightnit Martha Stewart bedsheet from K-Mart, but a T-shirt will work here. No coffee filters won't be needed here. And a strainer isn't going to either. They are later squeezed in a press to remove most of the solution from the wet fabric. The solution is then poured into large cooking pots and re-heated, but not boiled.

5.Ammonium chlorideIt is sold out there.buy it and use it!! No substitutions) is added to the heated calcium morphenate solution to adjust the alkalinity to a pH of 8 to 9, and the solution is then allowed to cool. Within one or two hours, the morphine base and the unextracted codeine base precipitate out of the solution and settle to the bottom of the cooking pot.

6.The solution is then poured off through cloth filters. Any solid morphine base chunks in the solution will remain on the cloth. The morphine base is removed from both the cooking pot and from the filter cloths, wrapped and squeezed in cloth, and then dried on a cookie sheet with waxpaper on top of it top rack in the oven 200 degrees(pre-heated)ten minutes.and then five minutes(probably about three minutes if using 10 grams or so of opium). When dry, the crude morphine base is a coffee-colored powder.

7.This 'crude' morphine base, may be further purified by dissolving it in hydrochloric acid, adding activated charcoal, re-heating and re-filtering. The solution is filtered several more times, and the morphine (morphine hydrochloride) is then dried in the same fashion as before(oven etc.)



The conversion of morphine hydrochloride to heroin base is a relatively simple and inexpensive procedure. The necessary chemicals are readily available industrial chemicals. The equipment is very basic and quite portable. Heroin conversion laboratories are generally located in isolated, rural areas due to the telltale odors of the lab's chemicals. [b]Acetic anhydride,<---again, no substituitions) in particular, is a key chemical with the easily identified very pungent odor of pickles.

Heroin synthesis is a two-step process which generally requires twelve to fourteen hours to complete. Heroin base is the intermediate product. Typically, morphine hydrochloride bricks are pulverized and the dried powder is then placed in an enamel or stainless steel cooking pot. The liquid acetic anhydride is then added. The pot lid is tied or clamped on, with a damp towel used for a gasket. The pot is carefully heated for about two hours, below boiling, at a constant temperature of 185 degrees Fahrenheit. It is never allowed to boil or to become so hot as to vent fumes. It is agitated by tilting and swirling until all of the morphine has dissolved. Acetic anhydride reacts with the morphine to form diacetylmorphine (heroin). This acetylation process will work either with morphine hydrochloride.

When cooking is completed, the pot is cooled and opened. The morphine and the acetic anhydride have now become chemically bonded, creating an impure form of diacetylmorphine (heroin). Water is added at three times the volume of acetic anhydride and the mixture is stirred. Activated charcoal is added and mixed by stirring and the mixture is then filtered to remove colored impurities. Solids remaining on the filter are discarded. Sodium carbonate, (used at 2.5-times the amount of morphine,) is dissolved in hot water and added slowly to the liquid until effervescence stops.

This precipitates the heroin base which is then filtered and dried by heating in a steam bath for an hour. For each pound of morphine, about 11 ounces of crude heroin base is formed. The heroin base may be dried, to heroin by refining and then converted it to heroin hydrochloride, the water-soluble salt form of heroin.



To the heroin base mixture in the pot, water is added at three times the volume of acetic anydride and mixed by stirring. A small amount of chloroform<---you got it!1 no subs!!) is added. The mixture is stirred and then allowed to stand for twenty minutes. Doing so precipitates highly-colored impurities and a red, greasy liquid. The water layer is carefully poured off and saved in a clean pot, leaving the red grease in the pot. In a clean pot, activated charcoal is stirred into the aqueous solution and is filtered to remove solid impurities. The decolorizing effects of the charcoal, combined with the chloroform treatment, will leave a light yellow solution. The use of charcoal is repeated one or more times, until the solution is colorless.

Approximately 1.1 grams of sodium carbonate per 0.5 grams of morphine is dissolved in hot water and added slowly to the mixture until the effervescence stops. This precipitates the heroin base which is then filtered and dried by heating on a steam bath. The heroin base is heated until dryness is complete, an imperative for the preparation of heroin suitable for injections. The powder should be very white at this stage. If not white, the base is redissolved in diluted acid, treated repeatedly with activated charcoal, reprecipitated and dried. The ultimate purity and color of the resulting heroin hydrochloride depends largely on the quality of the heroin base.

The following optional steps are sometimes taken by skilled heroin chemists to increase quality.

For each pound of heroin base 1,100 milliliters of ethyl alcohol is heated to boiling. The heroin base is added and stirred until completely dissolved. The heated solution is then quickly filtered through a Büchner funnel that has been preheated and poured into a heated flask. This hot filtration removes the traces of sodium carbonate that remained in the base. The solution is quickly cooled in an ice bath, where it becomes very thick; like ice cream. The substance is put into a pan and set in a large refrigerator. A fan is set to blow across the pan to cause slow evaporation of the alcohol while the paste crystallizes. After several hours, it is vacuum-filtered. The filtrate, pure ethyl alcohol, is re-used. The solid material, 'alcohol morphine base', is actually recrystallized heroin base.

The heroin product, either heroin base or recrystallized heroin base, is weighed. For each pound of solid product, 3,000 milliliters of ethyl alcohol, 3,000 milliliters of ether, and 102 milliliters of concentrated hydrochloric acid are measured out. The solid is dissolved by heating with one-third of the alcohol and one-half of the acid. Another one-third of the acid is added and mixed by stirring. Next, acid is added slowly, drop by drop, until the product is completely converted to the hydrochloride. Two methods of testing this end product may be used. Either a drop of solution evaporates on a clean glass plate, leaving no trace of cloudiness in the residue, or a drop of the solution placed on Congo red paper causes the paper to turn blue.

Once the acid is added, the remaining alcohol is stirred in. Half of the ether is then added with stirring and the mixture is allowed to stand for fifteen minutes. It must be examined with great care since it is extremely volatile and flammable. Once the first small crystals are detected, the remaining ether is added at once. The vessel is stirred, covered and allowed to stand for twenty minutes to one hour. The mixture becomes nearly solid after an hour. At this point, it is filtered and the solids are collected and bagged-up.

Chemicals used to isolate morphine from opium include ammonium chloride, calcium carbonate (limestone), and calcium hydroxide (slaked lime). The precursor chemical normally used in the conversion of morphine to heroin is acetic anhydride. Chemical reagents used in the conversion process include sodium carbonate and activated charcoal. Chemical solvents needed are chloroform, ethyl alcohol (ethanol), ethyl ether and acetone. Other chemicals may be substituted for these preferred chemicals, but most or all of these preferred chemicals are readily available and are a must/necessary.



Looks like a crazy amount of effort and whatnots, but once the chemicals are purchased the motherfucker goes like a dream come true.



Simply follow this to the letter and it will produce.

Now I know nobody is gonna bother actually going to all this trouble for a measly 25-5o-odd grams of opium to begin with....I wouldn't either.

But man I did so helpme God make my own heroin and it is possible to do the same yourself if you go and grow some poppies score and scrape like I do every year and you too can enjoy a bounty of Natural Wonder called Morphine and its actlyed Mutation-Heroin.



Jam.

Jam, u da man!

yeah, SWIM's measly 110 gm.s of O aren't worth converting, but SWIM has grown before and has like a pound of seeds and will grow again.

'bout the mower action: this removed all the seeds, right? SWIM is pretty sure they are undesireable in the O.

also, i know this probably sounds dumb but : where does SWIM get acetic anhydride? does SWIM have to make it (if so, how)?

also, where does SWIM get ethyl ether? does SWIM have to make it (if so, how)?

the two chems SWIM mentioned in the preceding reply are very watched, aren't they?

Who uses them here?!

They are in Mexico and Columbia.



My source? Not even.



I got all mine from the same Merchant.

Jam.

hey Jam, i know this isn't necessarily the right place for it but, since you've been monitoring the threads i thought i'd supply some results of my searches (phos acid) for u (even though u are probably aware of them already):

http://www.chemical.net/cn_store/dept.asp?dept%5Fid=200421 http://www.labdepotinc.com/chemical_details.aspx?pid=P1100 http://chemistry.about.com/cs/suppliers/ http://dmoz.org/Science/Chemistry/Products_and_Services/Supplies/Laboratory_Reagents/ http://www.thecatalyst.org/m12suppl.html

still have a few more hiding on the PC, will flush them out eventually.

thanx for all the help.

It's that time of year you guys. Time to plant poppies!! <A HREF="http://users.pandora.be/eforum/emoticons4u/music/musik06.gif">http://users.pandora.be/eforum/emoticons4u/music/musik06.gif" width="90" height="90 (http://users.pandora.be/eforum/emoticons4u/music/musik06.gif" width="90" height="90)</A>



Jam.

Does anyone in the pacific NW area know what month and week (approximately) the poppies should be ready to scrape?

I spread a bunch of seeds out two weeks ago if this helps.

70-85 days from date of germination. So subtract 14 days off 85 and 71 days at the most.

Jam.

Just another note, 1.33003 g of morphine sulfate = 1 g of morphine. Don't forget this

Just a little stoichometry. Because morphine sulfate (MSO4) is a pentahydrate, one must take this into account. Therefore for 1 g morphine, you need 1.33003 g MSO4. Random but useful nonetheless

Jam,

what is done differently in the manufacture of black tar?

Swij had a nice little garden of Persian Whites growing in his closet until yesterday, when his crazy pissed off girlfriend opened the door and kicked the whole works! Smashed his light, destroyed his garden, all is lost. Dumb Bitch. It was all Swij could do not to smack the shit out of her.

Swij tried to recover a couple of the plants and stuck them in the window, hopefully they'll pull through.

City apartment living makes it difficult to grow poppies outdoors, although I'm thinking about doing it anyways. Chances are nobody will know what they are anyways.

Black tar is just like peanutbutter dope. It's more or less reacted and reduced and converted with no filtering so thus, the end result isn't a salt(morphine hydrochloride, heroin hydrochloride, just like peanutbutter dope isn't a true meth hydrochloride in and of itself since it'd have to be at least white in color).

But the difference between paenutbutter and blacktar is the impurities in the blacktar aren't as toxin-laden as peanutbutter meth as it has iodides amongst other things all wrapped up in one gooey mass.

Black tar is reported to be more potent by its users than powdered heroin but this is due to powdered being cut/diluted down with usually no less than 50% MSM.

Blacktar can't be cut and isn't cut and has one-fourth the bulk per kilo as powdered. The Mexicans basically were never taught how to make heroin so they went on their own and never could figure out how to precipitate so the opium stayed with its consistancy as it was processed.

And the brown powdered heroin Mexico has produced since the 1950's is made by a handful of families in Durango who aren't interested in even thinking about talking their business outside their blood.

If you want powdered product you must precipitate no matter what you're trying to produce.



Jam.

ground is thawed and awaiting SWIM's green thumb to work in the cow shit and compost. (zone 7)

can't wait to b a johnny poppy seed again!



SWIM did this about 10 yr.s ago and was pleased, now with the experience of age and the helpful advice of Jam, he plans on stepping up the scale of production and try some purification to boot.

drooling of the potential results!