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| Laboratory Tips Safety proceedures, test reagents, drilling rubber stoppers, bending glass tubes, etc. Contributed to by chemists. |
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#1
 2003-07-09, 06:14
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GOD_Burnsout 
Regular
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Isomer Questions
Is most meth you find on the streets racemic or dextro or wha? I would ask over in BLTC but I don't think most of them would even know what an isomer is.
Is there any way to seperate optical isomers (or any other kind of isomer that would result in a potent and non-potent pair) from a racemic mixture without some special device?
Is dextro-amphetamine the same as amphetamine's S isomer? (I realize this wouldn't mean it's like that for all drugs)
Does every chemical have isomers (such as cocaine)? If not, what determines if a chemical has isomers or not?
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#2
 2003-07-09, 14:24
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Synthorcist 
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Re: Isomer Questions
Methamphetamine (and amphetamine) have only one chiral (handed) centre. This is basically which way the methyl (CH3) group next to the amine (NH) points.
The S (dextro) isomers of methamphetamine and amphetamine are the more active, but this is reversed in the case of some other amphetamine based compounds (Ie. MDMA, where the R (levo) isomer is more active. See Pihkal #109).
Street meth is usually either synthesised from racemic ephedrine in which case it racemic or less commonly diverted from medical sources in which case it will be d-methamphetamine.
The resolution of racemic amphetamine is possible, but rather involved.
Try: http://www.rhodium.ws/chemistry/amphetamine.resolution.html
And yes, all but the simplist chemicals have isomers.
Synth
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#3
 2003-07-09, 16:27
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GOD_Burnsout 
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Re: Isomer Questions
Rockinin!
Thanks a lot.
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