Monograph number: 4582
Title: Guaifenesin
CAS Registry number: [93-14-1]
CA name(s): 3-(2-Methoxyphenoxy)-1,2-propanediol;
Additional name(s): glycerol mono(2-methoxyphenyl) ether; glycerol .alpha.-(2-methoxyphenyl) ether; guaiacyl glyceryl ether; glyceryl guaiacyl ether; glycerol guaiacolate; .alpha.-glyceryl guaiacol ether; o- methoxyphenyl glyceryl ether; 1,2-dihydroxy-3-(2-methoxyphenoxy)propane; guaiacol glyceryl ether; guaiphenesin; guaiacuran;
Trade names(s): Actifed-C (Burroughs Wellcome); Calmipan; Colrex Expectorant (Rowell); Equicol (Burns-Bio); Glycodex (Burns-Bio); Guaiamar; Guayanesin; Miocaina; Myocaine; Myoscain; Oresol; Oreson; Relaxil G; Reorganin; Respenyl; Resyl (Ciba); Robitussin (Robins); Sirotol (Stada); Tenntuss; Tulyn.
Drug code(s): MY-301; XL-90;
Molecular formula: C10H14O4
Molecular weight: 198.22
Composition: C 60.59%, H 7.12%, O 32.29%.
Literature references: Centrally acting muscle relaxant with expectorant properties. Prepn: Marle, J. Chem. Soc. 101, 305 (1912); Yale et al., J. Am. Chem. Soc. 72, 3710 (1950); Roviralta, Astoul, Span. pat. 212,920 (1954), C.A. 49, 8332b (1955). Prepn from 2-methoxyphenol and glycidol: W. Merk et al., Ger. pat. 3,106,995 corresp to U.S. pat. 4,390,732 (1982, 1983 to Degussa AG). GLC determn in blood: W. R. Maynard, R. B. Bruce, J. Pharm. Sci. 59, 1346 (1970). Clinical use in chronic respiratory disease: D. G. Workman et al., Curr. Ther. Res. 7, 665 (1965). Clinical efficacy as antitussive: J. J. Kuhn et al., Chest 82, 713 (1982). Pharmacokinetics and cardiopulmonary effects in horses: J. A. E. Hubbell et al., Am. J. Vet. Res. 41, 1751 (1980). Use in equine anesthesia: J. L. Grandy, W. N. McDonell, J. Am. Vet. Med. Assoc. 176, 619 (1980); G. J. Brouwer, Eq. Vet. J. 17, 133 (1985).
Properties: Minute rhombic prisms from ether, mp 78.5-79 deg. bp19215 deg. Slightly bitter aromatic taste. One gram dissolves in 20 ml water at 25 deg. Much more sol in hot water; freely sol in ethanol; sol in chloroform, glycerol, propylene glycol, DMF; moderately sol in benzene. Practically insol in petr ether.
Melting point: 78.5-79
Boiling point: 215
Derivative: Mixture with theophylline (1:1)
CAS Registry number: [5634-38-8]
Additional name(s): guaithylline,
Trade name(s): Eclabron (U.S. Ethicals)
THERAP CAT: Expectorant; guaithylline also as bronchodilator.
THERAP CAT (VET): Expectorant; muscle relaxant.
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so it is like this an a/b with good naptha works well against guffy. but what else is in those pills ?
no a soak in a non polar wont do anything kbk use a a/b with pet either you have to move the sudo in to something that the guffy wont go into
[This message has been edited by pikk (edited 07-05-2003).]
[This message has been edited by pikk (edited 07-05-2003).]
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