Swim has 100 morphine sulfates does anyone have any good ideas for adding 2 acetal groups to the morphine molecule using readily avalible precursers also does swim have to turn it into the freebase form before adding the acetal groups any responces from a capable chemist would be GREATLY appreciated and swim would feel forever indebted to said chemist

This looks like a job for...tryp!!!

if anyone can help me find a ghetto rigged way to make the inert atmosphere then I could just use the acetic anhydryde I know that N will work

you don't need an inert atmosphere to acetylate morphine with acetic anhydride. You should have a perfectly dry reaction and atmosphere. Just reflux with a molar excess of anhydride under a moisture trap and then workup, I'll leave the solvents and other details to you.

Man that would be nice to have that much morphine.

Theoretically, one could dissolve these morph sulfates in an acid, say vinegar? One could then then bubble acetylene gas through this solution, and the diacetyl-morphine would precipitate out. Acetylides are rarely soluble. I am unsure of this however, so it would be advantagous to try a nano reaction first to make sure.

This type of synth is used in explosives to convert nitrates to acetylides. A sulfate group is easier to react than a nitrate group so this will probably work. Likewise, a nitrate group is easier to react then an acetylide group. The whole she-bang revolves around breaking you compound into two distinct ions, a morphine ion and a sulfate ion, one then substitues a more electronegative ion for the original ion. It may be neccesary to nitrate SWIM's morph before acetylizing it.

I would have thought a simple sn1 reation my self ionize mophine and then replace It was on the rhodium site that I saw about the inert atmosphere stuff I dont see anypart that would react oxygen or anything else in the air .... thankx for some insight fellas