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Mad Scientists Science and Mathematics discussion-- theories, arguments, citations, proofs and pudding.

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 #1 
Old 2008-11-29, 05:45
Moderator
 
toronto
Default Question about transplanted organ growth.

Ok. Bear with me i'm a little stoned. Hopefully one of you scientitians can entertain one of my potheadisms.

There is some local news about a man who recently donated a portion of his liver to a 6 month old child who needed it. Now, as this child ages this portion of liver will need to grow along with the child. My question is, as this liver grows does it proliferate according to the genetic code (DNA) of the donor or of the recipient?

I suppose this question applies to cellular genesis in general. As cells in the liver die and regenerate, to what extent is the dna of the donor stable? Is there some process by which the recipient dna trans-mutates (???) the donor dna into its own eventually, or does the donated organ retain its genetic integrity throughout aging?
 #2 
Old 2008-11-29, 10:14
Mantikore Mantikore is offline
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Default Re: Question about transplanted organ growth.

right im not an expert of biology, but im going to guess that the DNA of said liver is of the same DNA as the donor.

the reason behind it is that organ growth and repair is done by mitosis, which creates exact copies of existing cells and im pretty sure that the DNA wont fuse together or anything.

though im sure that in normal circumstances, the body will recognise the liver as being foreign and will attack it in pretty much in every case of an organ donation (there are a few rare cases where this doesnt occur) so the child will probably have to take some immuno suppressant drugs to prevent this, though the child will suffer from more infections in the future
 #3 
Old 2008-11-29, 15:52
Moderator
 
toronto
Default Re: Question about transplanted organ growth.

Thanks for the answer, it makes sense. So, the developing organ remains totally foreign at all times. Pretty interesting stuff.
 
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